Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice
Objective: To evaluate the in vivo antischistosomal activities of the crude extracts of Echinops kebericho Mesfin (E. kebericho) root and Hagenia abyssinica (Bruce) J.F. Gmel (H. abyssinica) flower. Methods: Mice were infected with (150 ± 10) Schistosoma mansoni cercariae by paddling technique. Crud...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
| Series: | Asian Pacific Journal of Tropical Medicine |
| Subjects: | |
| Online Access: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=10;spage=570;epage=575;aulast=Alemu |
| _version_ | 1819076586679304192 |
|---|---|
| author | Yonas Alemu Zeleke Mekonnen Ahmed Zeynudin Moti Yohannes Abdissa Biruksew Sultan Suleman |
| author_facet | Yonas Alemu Zeleke Mekonnen Ahmed Zeynudin Moti Yohannes Abdissa Biruksew Sultan Suleman |
| author_sort | Yonas Alemu |
| collection | DOAJ |
| description | Objective: To evaluate the in vivo antischistosomal activities of the crude extracts of Echinops kebericho Mesfin (E. kebericho) root and Hagenia abyssinica (Bruce) J.F. Gmel (H. abyssinica) flower. Methods: Mice were infected with (150 ± 10) Schistosoma mansoni cercariae by paddling technique. Crude extracts were administered orally for five consecutive days at doses of 300, 600 and 1 200 mg/kg/day along with 200 mg/kg/day praziquantel and 3% tween 80 given as a control. Results: E. kebericho root extract showed a statistically significant (P < 0.05) reduction in fecal egg count of 64.44%, 42.96% & 26.82% and worm burden of 65.71%, 47.86% & 31.43% at treatment doses of 1 200 mg/kg/day, 600 mg/kg/day and 300 mg/kg/day, respectively. Similarly, H. abyssinica flower extracts showed a significant (P < 0.05) reduction in fecal egg count up to 84.57%, 77.06% & 63.89% and worm burden of 91.43%, 81.43% & 70.71% at a respective dose levels. In addition, a significant (P < 0.05) reduction in liver granuloma score was observed in all H. abyssinica administered dose groups and E. kebericho at 1 200 mg/kg/day dose group as compared to infected untreated control group. Conclusions: H. abyssinica and E. kebericho crude extracts show a promising antischistosomal activity. |
| first_indexed | 2024-12-21T18:43:40Z |
| format | Article |
| id | doaj.art-f26e8d4e6417413b9ac1f05f7947a2f7 |
| institution | Directory Open Access Journal |
| issn | 2352-4146 |
| language | English |
| last_indexed | 2024-12-21T18:43:40Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj.art-f26e8d4e6417413b9ac1f05f7947a2f72022-12-21T18:53:57ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462018-01-01111057057510.4103/1995-7645.244517Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino miceYonas AlemuZeleke MekonnenAhmed ZeynudinMoti YohannesAbdissa BiruksewSultan SulemanObjective: To evaluate the in vivo antischistosomal activities of the crude extracts of Echinops kebericho Mesfin (E. kebericho) root and Hagenia abyssinica (Bruce) J.F. Gmel (H. abyssinica) flower. Methods: Mice were infected with (150 ± 10) Schistosoma mansoni cercariae by paddling technique. Crude extracts were administered orally for five consecutive days at doses of 300, 600 and 1 200 mg/kg/day along with 200 mg/kg/day praziquantel and 3% tween 80 given as a control. Results: E. kebericho root extract showed a statistically significant (P < 0.05) reduction in fecal egg count of 64.44%, 42.96% & 26.82% and worm burden of 65.71%, 47.86% & 31.43% at treatment doses of 1 200 mg/kg/day, 600 mg/kg/day and 300 mg/kg/day, respectively. Similarly, H. abyssinica flower extracts showed a significant (P < 0.05) reduction in fecal egg count up to 84.57%, 77.06% & 63.89% and worm burden of 91.43%, 81.43% & 70.71% at a respective dose levels. In addition, a significant (P < 0.05) reduction in liver granuloma score was observed in all H. abyssinica administered dose groups and E. kebericho at 1 200 mg/kg/day dose group as compared to infected untreated control group. Conclusions: H. abyssinica and E. kebericho crude extracts show a promising antischistosomal activity.http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=10;spage=570;epage=575;aulast=Alemuschistosoma mansoniechinops keberichohagenia abyssinicacrude extractantischistosomal activityethiopia |
| spellingShingle | Yonas Alemu Zeleke Mekonnen Ahmed Zeynudin Moti Yohannes Abdissa Biruksew Sultan Suleman Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice Asian Pacific Journal of Tropical Medicine schistosoma mansoni echinops kebericho hagenia abyssinica crude extract antischistosomal activity ethiopia |
| title | Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
| title_full | Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
| title_fullStr | Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
| title_full_unstemmed | Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
| title_short | Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
| title_sort | anti schistosomal activities of echinops kebericho mesfin root and hagenia abyssinica bruce j f gmel flower part crude extracts in swiss albino mice |
| topic | schistosoma mansoni echinops kebericho hagenia abyssinica crude extract antischistosomal activity ethiopia |
| url | http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=10;spage=570;epage=575;aulast=Alemu |
| work_keys_str_mv | AT yonasalemu antischistosomalactivitiesofechinopskeberichomesfinrootandhageniaabyssinicabrucejfgmelflowerpartcrudeextractsinswissalbinomice AT zelekemekonnen antischistosomalactivitiesofechinopskeberichomesfinrootandhageniaabyssinicabrucejfgmelflowerpartcrudeextractsinswissalbinomice AT ahmedzeynudin antischistosomalactivitiesofechinopskeberichomesfinrootandhageniaabyssinicabrucejfgmelflowerpartcrudeextractsinswissalbinomice AT motiyohannes antischistosomalactivitiesofechinopskeberichomesfinrootandhageniaabyssinicabrucejfgmelflowerpartcrudeextractsinswissalbinomice AT abdissabiruksew antischistosomalactivitiesofechinopskeberichomesfinrootandhageniaabyssinicabrucejfgmelflowerpartcrudeextractsinswissalbinomice AT sultansuleman antischistosomalactivitiesofechinopskeberichomesfinrootandhageniaabyssinicabrucejfgmelflowerpartcrudeextractsinswissalbinomice |