Factors Associated with Mortality Among Severe Omicron Patients for COVID-19
Shuting Wu, Guichan Liao, Jingchun Mao, Haiming Yan, Juanjuan Chen, Jie Peng Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Jie Peng, Department of Infectious Diseases, Nanfang Hospital, Southern Medical Universi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-04-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/factors-associated-with-mortality-among-severe-omicron-patients-for-co-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797222279055147008 |
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| author | Wu S Liao G Mao J Yan H Chen J Peng J |
| author_facet | Wu S Liao G Mao J Yan H Chen J Peng J |
| author_sort | Wu S |
| collection | DOAJ |
| description | Shuting Wu, Guichan Liao, Jingchun Mao, Haiming Yan, Juanjuan Chen, Jie Peng Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Jie Peng, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic of China, Tel +8613802515784, Fax +86 20 87719653, Email Pjie138@163.comPurpose: The purpose of the study was to explore the potential risk factors of mortality in patients with severe pneumonia during the omicron pandemic in South China in 2022.Methods: Clinical data was collected from patients hospitalized with omicron COVID-19. Then, patients were categorized into the non-survival and survival groups. A comprehensive analysis was conducted to analyze the factors associated with negative outcome in individuals suffering from severe omicron COVID-19.Results: In this study, 155 severe COVID-19 patients were included, comprising 55 non-survivors and 100 survivors. Non-survivors, in comparison to survivors, exhibited elevated levels of various biomarkers including neutrophil count, hypersensitive troponin T, urea, creatinine, C-reactive protein, procalcitonin, interleukin-6, plasma D-dimer, and derived neutrophil-to-lymphocyte ratio (dNLR) (P < 0.05). They also displayed reduced lymphocyte count, platelet count, and albumin levels (P < 0.05) and were more prone to developing comorbidities, including shock, acute cardiac and renal injury, acute respiratory distress syndrome, coagulation disorders, and secondary infections. Platelet count (PLT) < 100 × 10^/L, interleukin-6 (IL-6) > 100 pg/mL, and dNLR > 5.0 independently contributed to the risk of death in patients suffering from severe COVID-19.Conclusion: PLT, IL-6, and dNRL independently contributed to the risk of mortality in patients with severe pneumonia during the 2022 omicron pandemic in South China.Keywords: COVID-19, omicron, severe infection, dNLR, risk factors |
| first_indexed | 2024-04-24T13:18:48Z |
| format | Article |
| id | doaj.art-f270156e40eb457c845c0e7742f6563f |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-24T13:18:48Z |
| publishDate | 2024-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-f270156e40eb457c845c0e7742f6563f2024-04-04T16:51:52ZengDove Medical PressInfection and Drug Resistance1178-69732024-04-01Volume 171309131991683Factors Associated with Mortality Among Severe Omicron Patients for COVID-19Wu SLiao GMao JYan HChen JPeng JShuting Wu, Guichan Liao, Jingchun Mao, Haiming Yan, Juanjuan Chen, Jie Peng Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Jie Peng, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic of China, Tel +8613802515784, Fax +86 20 87719653, Email Pjie138@163.comPurpose: The purpose of the study was to explore the potential risk factors of mortality in patients with severe pneumonia during the omicron pandemic in South China in 2022.Methods: Clinical data was collected from patients hospitalized with omicron COVID-19. Then, patients were categorized into the non-survival and survival groups. A comprehensive analysis was conducted to analyze the factors associated with negative outcome in individuals suffering from severe omicron COVID-19.Results: In this study, 155 severe COVID-19 patients were included, comprising 55 non-survivors and 100 survivors. Non-survivors, in comparison to survivors, exhibited elevated levels of various biomarkers including neutrophil count, hypersensitive troponin T, urea, creatinine, C-reactive protein, procalcitonin, interleukin-6, plasma D-dimer, and derived neutrophil-to-lymphocyte ratio (dNLR) (P < 0.05). They also displayed reduced lymphocyte count, platelet count, and albumin levels (P < 0.05) and were more prone to developing comorbidities, including shock, acute cardiac and renal injury, acute respiratory distress syndrome, coagulation disorders, and secondary infections. Platelet count (PLT) < 100 × 10^/L, interleukin-6 (IL-6) > 100 pg/mL, and dNLR > 5.0 independently contributed to the risk of death in patients suffering from severe COVID-19.Conclusion: PLT, IL-6, and dNRL independently contributed to the risk of mortality in patients with severe pneumonia during the 2022 omicron pandemic in South China.Keywords: COVID-19, omicron, severe infection, dNLR, risk factorshttps://www.dovepress.com/factors-associated-with-mortality-among-severe-omicron-patients-for-co-peer-reviewed-fulltext-article-IDRcovid-19omicronsevere infectiondnlrrisk factors |
| spellingShingle | Wu S Liao G Mao J Yan H Chen J Peng J Factors Associated with Mortality Among Severe Omicron Patients for COVID-19 Infection and Drug Resistance covid-19 omicron severe infection dnlr risk factors |
| title | Factors Associated with Mortality Among Severe Omicron Patients for COVID-19 |
| title_full | Factors Associated with Mortality Among Severe Omicron Patients for COVID-19 |
| title_fullStr | Factors Associated with Mortality Among Severe Omicron Patients for COVID-19 |
| title_full_unstemmed | Factors Associated with Mortality Among Severe Omicron Patients for COVID-19 |
| title_short | Factors Associated with Mortality Among Severe Omicron Patients for COVID-19 |
| title_sort | factors associated with mortality among severe omicron patients for covid 19 |
| topic | covid-19 omicron severe infection dnlr risk factors |
| url | https://www.dovepress.com/factors-associated-with-mortality-among-severe-omicron-patients-for-co-peer-reviewed-fulltext-article-IDR |
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