Perineural treatment with anti-TNF-α antibody ameliorates persistent allodynia and edema in novel mouse models with complex regional pain syndrome

Perineural treatment with anti-TNF-α antibody ameliorates persistent allodynia and edema in novel mouse models with complex regional pain syndrome

Complex regional pain syndrome (CRPS) is an intractable chronic pain syndrome with various signs and symptoms including allodynia/hyperalgesia, edema, swelling, and skin abnormalities. However, a definitive therapeutic treatment for CRPS has not been established. In CRPS patients, inflammatory cytok...

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Bibliographic Details
Main Authors: Shiho Shibata, Hideaki Tagashira, Takayuki Nemoto, Satomi Kita, Tomo Kita, Yasuharu Shinoda, Kouzaburo Akiyoshi, Ken Yamaura, Takahiro Iwamoto
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Complex regional pain syndrome
Anti-TNF-α antibody
Mechanical allodynia
Edema
Sciatic nerve
Online Access:http://www.sciencedirect.com/science/article/pii/S134786132300035X

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