Experimental Infection of Ground Squirrels (Spermophilus tridecemlineatus) with Monkeypox Virus
A proposed new small-animal (rodent) model for studying the pathogenesis and treatment of severe orthopoxvirus infections is described. Thirteen-lined ground squirrels (Spermophilus tridecemlineatus) were infected intraperitoneally and intranasally with monkeypox virus (MPXV). A fulminant illness de...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2004-09-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/10/9/04-0310_article |
| _version_ | 1819100851150520320 |
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| author | Robert B. Tesh Douglas M. Watts Elena Sbrana Marina Siirin Vsevolod L. Popov Shu-Yuan Xiao |
| author_facet | Robert B. Tesh Douglas M. Watts Elena Sbrana Marina Siirin Vsevolod L. Popov Shu-Yuan Xiao |
| author_sort | Robert B. Tesh |
| collection | DOAJ |
| description | A proposed new small-animal (rodent) model for studying the pathogenesis and treatment of severe orthopoxvirus infections is described. Thirteen-lined ground squirrels (Spermophilus tridecemlineatus) were infected intraperitoneally and intranasally with monkeypox virus (MPXV). A fulminant illness developed in all animals, and they died 6–9 days after infection. Virus was cultured from the blood and oropharynx several days before death; at necropsy, all of the organs tested contained relatively high titers of MPXV. The major pathologic findings were in the liver, which showed centrilobular necrosis, steatosis, and basophilic inclusion bodies in hepatocytes. Splenic necrosis was also observed, as well as interstitial inflammation in the lungs. The pathologic features of MPXV in ground squirrels is similar to that described with MPXV in macaques and severe variola (smallpox) virus infection in humans. |
| first_indexed | 2024-12-22T01:09:20Z |
| format | Article |
| id | doaj.art-f271016fb6d24e55afe86c763373fcbc |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-22T01:09:20Z |
| publishDate | 2004-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-f271016fb6d24e55afe86c763373fcbc2022-12-21T18:44:01ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592004-09-011091563156710.3201/eid1009.040310Experimental Infection of Ground Squirrels (Spermophilus tridecemlineatus) with Monkeypox VirusRobert B. TeshDouglas M. WattsElena SbranaMarina SiirinVsevolod L. PopovShu-Yuan XiaoA proposed new small-animal (rodent) model for studying the pathogenesis and treatment of severe orthopoxvirus infections is described. Thirteen-lined ground squirrels (Spermophilus tridecemlineatus) were infected intraperitoneally and intranasally with monkeypox virus (MPXV). A fulminant illness developed in all animals, and they died 6–9 days after infection. Virus was cultured from the blood and oropharynx several days before death; at necropsy, all of the organs tested contained relatively high titers of MPXV. The major pathologic findings were in the liver, which showed centrilobular necrosis, steatosis, and basophilic inclusion bodies in hepatocytes. Splenic necrosis was also observed, as well as interstitial inflammation in the lungs. The pathologic features of MPXV in ground squirrels is similar to that described with MPXV in macaques and severe variola (smallpox) virus infection in humans.https://wwwnc.cdc.gov/eid/article/10/9/04-0310_articlemonkeypoxpoxvirus infectionorthopoxvirusexperimental infectionanimal modelresearch |
| spellingShingle | Robert B. Tesh Douglas M. Watts Elena Sbrana Marina Siirin Vsevolod L. Popov Shu-Yuan Xiao Experimental Infection of Ground Squirrels (Spermophilus tridecemlineatus) with Monkeypox Virus Emerging Infectious Diseases monkeypox poxvirus infection orthopoxvirus experimental infection animal model research |
| title | Experimental Infection of Ground Squirrels (Spermophilus tridecemlineatus) with Monkeypox Virus |
| title_full | Experimental Infection of Ground Squirrels (Spermophilus tridecemlineatus) with Monkeypox Virus |
| title_fullStr | Experimental Infection of Ground Squirrels (Spermophilus tridecemlineatus) with Monkeypox Virus |
| title_full_unstemmed | Experimental Infection of Ground Squirrels (Spermophilus tridecemlineatus) with Monkeypox Virus |
| title_short | Experimental Infection of Ground Squirrels (Spermophilus tridecemlineatus) with Monkeypox Virus |
| title_sort | experimental infection of ground squirrels spermophilus tridecemlineatus with monkeypox virus |
| topic | monkeypox poxvirus infection orthopoxvirus experimental infection animal model research |
| url | https://wwwnc.cdc.gov/eid/article/10/9/04-0310_article |
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