Comparison of the fluorescein angiography-guided and indocyanine green angiography-guided photodynamic therapy in the treatment of non-resolving central serous chorioretinopathy
Abstract To compare the functional and anatomical outcome of fluorescein angiography (FA) versus indocyanine green angiography (ICGA) guided photodynamic therapy (PDT) in the treatment of non-resolving central serous chorioretinopathy (CSCR). In this prospective interventional case series, all patie...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28890-9 |
| _version_ | 1811171732170473472 |
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| author | Nazanin Ebrahimiadib Arash Mirzaei Shaghayegh Esfandiarifard Sonal Tuli Ehsan Najibzadeh Marjan Imani Fooladi Kaveh Fadakar |
| author_facet | Nazanin Ebrahimiadib Arash Mirzaei Shaghayegh Esfandiarifard Sonal Tuli Ehsan Najibzadeh Marjan Imani Fooladi Kaveh Fadakar |
| author_sort | Nazanin Ebrahimiadib |
| collection | DOAJ |
| description | Abstract To compare the functional and anatomical outcome of fluorescein angiography (FA) versus indocyanine green angiography (ICGA) guided photodynamic therapy (PDT) in the treatment of non-resolving central serous chorioretinopathy (CSCR). In this prospective interventional case series, all patients with non-resolving CSCR, defined as persistent SRF involving subfoveal area for at least three months, were nonrandomly assigned to receive either FA or ICGA-guided half dose PDT. Baseline and 4 months post-treatment data including best corrected visual acuity (BCVA), the status of foveal subretinal fluid, subfoveal choroidal thickness, choroidal vascularity index, pigment epithelial detachment area, treatment and PDT spot numbers were collected. Thirty-six eyes were included; 24 received ICGA-guided and 12 received FA-guided PDT. Overall, improvement in BCVA and choroidal parameters were observed in all patients. There was no significant difference in baseline parameters as well as follow-up measurements between groups. However, the mean total energy dose and spot number in the IGCA-guided PDT were significantly higher than the FA-guided PDT group (P = 0.001). Both FA-guided and ICGA-guided half-dose PDT were effective in the treatment of non-resolving CSCR, with favorable functional and anatomical outcome. In FA group, PDT with smaller spot sizes and fewer numbers of spots were applied. |
| first_indexed | 2024-04-10T17:18:55Z |
| format | Article |
| id | doaj.art-f271db1ac5b24326ba46cf5216cdcc97 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T17:18:55Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f271db1ac5b24326ba46cf5216cdcc972023-02-05T12:13:26ZengNature PortfolioScientific Reports2045-23222023-01-011311810.1038/s41598-023-28890-9Comparison of the fluorescein angiography-guided and indocyanine green angiography-guided photodynamic therapy in the treatment of non-resolving central serous chorioretinopathyNazanin Ebrahimiadib0Arash Mirzaei1Shaghayegh Esfandiarifard2Sonal Tuli3Ehsan Najibzadeh4Marjan Imani Fooladi5Kaveh Fadakar6Department of ophthalmology, Eye Research Center, Tehran University of Medical SciencesDepartment of ophthalmology, Eye Research Center, Tehran University of Medical SciencesDepartment of ophthalmology, Eye Research Center, Tehran University of Medical SciencesDepartment of Ophthalmology, University of FloridaDepartment of ophthalmology, Eye Research Center, Tehran University of Medical SciencesDepartment of Ophthalmology, University of PittsburghDepartment of ophthalmology, Eye Research Center, Tehran University of Medical SciencesAbstract To compare the functional and anatomical outcome of fluorescein angiography (FA) versus indocyanine green angiography (ICGA) guided photodynamic therapy (PDT) in the treatment of non-resolving central serous chorioretinopathy (CSCR). In this prospective interventional case series, all patients with non-resolving CSCR, defined as persistent SRF involving subfoveal area for at least three months, were nonrandomly assigned to receive either FA or ICGA-guided half dose PDT. Baseline and 4 months post-treatment data including best corrected visual acuity (BCVA), the status of foveal subretinal fluid, subfoveal choroidal thickness, choroidal vascularity index, pigment epithelial detachment area, treatment and PDT spot numbers were collected. Thirty-six eyes were included; 24 received ICGA-guided and 12 received FA-guided PDT. Overall, improvement in BCVA and choroidal parameters were observed in all patients. There was no significant difference in baseline parameters as well as follow-up measurements between groups. However, the mean total energy dose and spot number in the IGCA-guided PDT were significantly higher than the FA-guided PDT group (P = 0.001). Both FA-guided and ICGA-guided half-dose PDT were effective in the treatment of non-resolving CSCR, with favorable functional and anatomical outcome. In FA group, PDT with smaller spot sizes and fewer numbers of spots were applied.https://doi.org/10.1038/s41598-023-28890-9 |
| spellingShingle | Nazanin Ebrahimiadib Arash Mirzaei Shaghayegh Esfandiarifard Sonal Tuli Ehsan Najibzadeh Marjan Imani Fooladi Kaveh Fadakar Comparison of the fluorescein angiography-guided and indocyanine green angiography-guided photodynamic therapy in the treatment of non-resolving central serous chorioretinopathy Scientific Reports |
| title | Comparison of the fluorescein angiography-guided and indocyanine green angiography-guided photodynamic therapy in the treatment of non-resolving central serous chorioretinopathy |
| title_full | Comparison of the fluorescein angiography-guided and indocyanine green angiography-guided photodynamic therapy in the treatment of non-resolving central serous chorioretinopathy |
| title_fullStr | Comparison of the fluorescein angiography-guided and indocyanine green angiography-guided photodynamic therapy in the treatment of non-resolving central serous chorioretinopathy |
| title_full_unstemmed | Comparison of the fluorescein angiography-guided and indocyanine green angiography-guided photodynamic therapy in the treatment of non-resolving central serous chorioretinopathy |
| title_short | Comparison of the fluorescein angiography-guided and indocyanine green angiography-guided photodynamic therapy in the treatment of non-resolving central serous chorioretinopathy |
| title_sort | comparison of the fluorescein angiography guided and indocyanine green angiography guided photodynamic therapy in the treatment of non resolving central serous chorioretinopathy |
| url | https://doi.org/10.1038/s41598-023-28890-9 |
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