Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US
This study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US, expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and self-reported clinical information was collected from women who...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/13/4201 |
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| author | Liza Johannesson Giuliano Testa Menas M. Beshara Briget da Graca Jessica R. Walter Cristiano Quintini Nawar Latif Koji Hashimoto Elliott G. Richards Kathleen O’Neill |
| author_facet | Liza Johannesson Giuliano Testa Menas M. Beshara Briget da Graca Jessica R. Walter Cristiano Quintini Nawar Latif Koji Hashimoto Elliott G. Richards Kathleen O’Neill |
| author_sort | Liza Johannesson |
| collection | DOAJ |
| description | This study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US, expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and self-reported clinical information was collected from women who contacted any of the three US UTx programs from 2015 to July 2022. The three centers received 5194 inquiries about becoming a UTx recipient during the study timeframe. Among those reporting a cause of infertility, almost all of the reports (4066/4331, 94%) were absence of a uterus, either congenitally (794/4066, 20%) or secondary to hysterectomy (3272/4066, 80%). The mean age was 34 years, and 49% (2545/5194) had at least one child at the time of application. The two centers using living donors received 2217 inquiries about becoming living donors. The mean age was 34 years, and 60% (1330/2217) had given birth to ≥1 child. While most of the UTx clinical trial evidence has focused on young women with congenital absence of the uterus, these results show interest from a much broader patient population in terms of age, cause of infertility, and parity. These results raise questions about whether and to what extent the indications and eligibility criteria for UTx should be expanded as the procedure transitions from the experimental phase to being offered as a clinical treatment. |
| first_indexed | 2024-03-11T01:38:38Z |
| format | Article |
| id | doaj.art-f2757264d16e4bca9409880e8116a091 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T01:38:38Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f2757264d16e4bca9409880e8116a0912023-11-18T16:50:29ZengMDPI AGJournal of Clinical Medicine2077-03832023-06-011213420110.3390/jcm12134201Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the USLiza Johannesson0Giuliano Testa1Menas M. Beshara2Briget da Graca3Jessica R. Walter4Cristiano Quintini5Nawar Latif6Koji Hashimoto7Elliott G. Richards8Kathleen O’Neill9Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USAAnnette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USATX A&M College of Medicine, Texas A&M University, Dallas, TX 75231, USAAnnette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USADepartment of Obstetrics & Gynecology, Northwestern University, Chicago, IL 60611, USADepartment of General Surgery, Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19107, USADepartment of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH 44103, USAObstetrics and Gynecology and Women’s Health Institute, Cleveland Clinic, Cleveland, OH 44103, USADivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19107, USAThis study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US, expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and self-reported clinical information was collected from women who contacted any of the three US UTx programs from 2015 to July 2022. The three centers received 5194 inquiries about becoming a UTx recipient during the study timeframe. Among those reporting a cause of infertility, almost all of the reports (4066/4331, 94%) were absence of a uterus, either congenitally (794/4066, 20%) or secondary to hysterectomy (3272/4066, 80%). The mean age was 34 years, and 49% (2545/5194) had at least one child at the time of application. The two centers using living donors received 2217 inquiries about becoming living donors. The mean age was 34 years, and 60% (1330/2217) had given birth to ≥1 child. While most of the UTx clinical trial evidence has focused on young women with congenital absence of the uterus, these results show interest from a much broader patient population in terms of age, cause of infertility, and parity. These results raise questions about whether and to what extent the indications and eligibility criteria for UTx should be expanded as the procedure transitions from the experimental phase to being offered as a clinical treatment.https://www.mdpi.com/2077-0383/12/13/4201uterus transplantationrecipientliving donorhysterectomyinfertilityparity |
| spellingShingle | Liza Johannesson Giuliano Testa Menas M. Beshara Briget da Graca Jessica R. Walter Cristiano Quintini Nawar Latif Koji Hashimoto Elliott G. Richards Kathleen O’Neill Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US Journal of Clinical Medicine uterus transplantation recipient living donor hysterectomy infertility parity |
| title | Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US |
| title_full | Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US |
| title_fullStr | Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US |
| title_full_unstemmed | Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US |
| title_short | Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US |
| title_sort | awareness and interest in uterus transplantation over time analysis of those seeking surgical correction for uterine factor infertility in the us |
| topic | uterus transplantation recipient living donor hysterectomy infertility parity |
| url | https://www.mdpi.com/2077-0383/12/13/4201 |
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