Pharmacokinetic/Pharmacodynamic Analysis of Oral Calcium Fosfomycin: Are Urine Levels Sufficient to Ensure Efficacy for Urinary Tract Infections?

Pharmacokinetic/Pharmacodynamic Analysis of Oral Calcium Fosfomycin: Are Urine Levels Sufficient to Ensure Efficacy for Urinary Tract Infections?

Urinary tract infections (UTIs) are extremely common and a major driver for the use of antimicrobials. Calcium fosfomycin is an old antibiotic indicated for the treatment of UTIs; however, data about its urine pharmacokinetic profile are scarce. In this work, we have evaluated the pharmacokinetics o...

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Bibliographic Details
Main Authors: Alicia Rodríguez-Gascón, Ana Alarcia-Lacalle, María Ángeles Solinís, Ana del Pozo-Rodríguez, Zuriñe Abajo, María Cabero, Andrés Canut, Arantxa Isla
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceutics
Subjects:
urinary tract infections
calcium fosfomycin
PK/PD analysis
Monte Carlo simulation
Online Access:https://www.mdpi.com/1999-4923/15/4/1185

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