Mechanism of in vitro sensitization of temozolomide to MGMT+ glioma cell line by FM19G11

Mechanism of in vitro sensitization of temozolomide to MGMT+ glioma cell line by FM19G11

Objective To investigate whether FM19G11 affects the sensitivity of human-derived malignant glioma cell line T98G to temozolomide (TMZ) and underlying molecular mechanisms. Methods T98G cells were treated with 0, 0.5, 1 and 2 μmol/L of FM19G11 and TMZ separately and jointly. The CCK-8 assay and ce...

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Bibliographic Details
Main Author: FANG Huang-yi, YOU Chao-guo, PANG Chen, ZHANG Zhong-ding, ZHANG Zhe, KUANG Tong-shuai, SHENG Han-song
Format: Article
Language:zho
Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2021-04-01
Series:Jichu yixue yu linchuang
Subjects:
glioblastoma|fm19g11|temozolomide|hypoxia inducible factor 1α|o6-methylguanine dna-methyltransferase
Online Access:http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a200139.pdf

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http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a200139.pdf

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