A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye

A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye

The autoimmune disorder, Sjögren’s syndrome (SS), is characterized by lymphocytic infiltration and loss of function of exocrine glands such as the lacrimal gland (LG) and salivary gland. SS-associated changes in the LG are associated with the development of autoimmune-mediated dry eye disease. We ha...

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Bibliographic Details
Main Authors: Pang-Yu Hsueh, Yaping Ju, Adrianna Vega, Maria C. Edman, J. Andrew MacKay, Sarah F. Hamm-Alvarez
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
elastin-like polypeptide
intercellular adhesion molecule-1
Sjögren’s syndrome
dry eye
lymphocyte function-associated 1 antigen
Online Access:https://www.mdpi.com/1422-0067/21/8/2758

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