Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3

Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3

ABSTRACT Elaborate regulation of innate immunity is necessary for the host to effectively respond to invading pathogens. As an important component of antiviral immunity transcription factors, the stability and activity of interferon (IFN) regulatory factor 3 (IRF3) are tightly controlled via multipl...

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Bibliographic Details
Main Authors: Jian Wang, Hui Zheng, Chunsheng Dong, Sidong Xiong
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
antiviral immunity
deubiquitination
OTUD6B
Type I IFN
Online Access:https://journals.asm.org/doi/10.1128/mbio.00332-23

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