PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing in Mycobacteria

PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing in Mycobacteria

New therapeutic strategies for the rapid and effective treatment of drug-resistant tuberculosis are highly desirable, and their development can be drastically accelerated by facile genetic manipulation methods in Mycobacterium tuberculosis (M. tuberculosis). Clustered regularly interspaced short pal...

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Bibliographic Details
Main Authors: Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang, Weizhong Chen, Xia Zhang, Xingxu Huang, Wei Chen, Quanjiang Ji
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Engineering
Subjects:
CRISPR
Cas9
Mycobacterium tuberculosis
Genome editing
Base editing
Online Access:http://www.sciencedirect.com/science/article/pii/S209580992200282X

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http://www.sciencedirect.com/science/article/pii/S209580992200282X

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