Neutralizing peripheral circulating IL1β slows the progression of ALS in a lentivirus‐infected OPTNE478G mouse model

Neutralizing peripheral circulating IL1β slows the progression of ALS in a lentivirus‐infected OPTNE478G mouse model

Abstract Background Amyotrophic lateral sclerosis (ALS) is irreversible and fatal within 3–5 years, with limited options for treatment. It is imperative to develop a symptom‐based treatment that may increase the survival of ALS patients and improve their quality of life. Inflammation status, especia...

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Bibliographic Details
Main Authors: Wen‐Bao Hu, Xin Wang, Zhi‐Lin Pang, Ran Duan, Chun‐Gu Hong, Zheng‐Zhao Liu
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Animal Models and Experimental Medicine
Subjects:
amyotrophic lateral sclerosis
inflammation
interleukin 1β
neurodegeneration
optineurin
Online Access:https://doi.org/10.1002/ame2.12297

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