Pericoronary fat attenuation index in computed tomography angiography is associated with mortality in end-stage renal disease
Background An increased pericoronary fat attenuation index (FAI) on computed tomography angiography (CTA) is associated with increased all-cause and cardiac mortality in the general population. However, the ability of pericoronary FAI to predict long-term outcomes in chronic kidney disease (CKD) pat...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2022-01-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.krcp-ksn.org/upload/pdf/j-krcp-21-090.pdf |
| _version_ | 1828191039631917056 |
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| author | Nam-Jun Cho Bo Da Nam Samel Park Hyoungnae Kim Hyunjin Noh Jin Seok Jeon Dong Cheol Han Eun Young Lee Hyo-Wook Gil Soon Hyo Kwon |
| author_facet | Nam-Jun Cho Bo Da Nam Samel Park Hyoungnae Kim Hyunjin Noh Jin Seok Jeon Dong Cheol Han Eun Young Lee Hyo-Wook Gil Soon Hyo Kwon |
| author_sort | Nam-Jun Cho |
| collection | DOAJ |
| description | Background An increased pericoronary fat attenuation index (FAI) on computed tomography angiography (CTA) is associated with increased all-cause and cardiac mortality in the general population. However, the ability of pericoronary FAI to predict long-term outcomes in chronic kidney disease (CKD) patients is unknown. Methods In this single-center retrospective longitudinal cohort study, we assessed the utility of CTA-based pericoronary FAI measurement to predict mortality of CKD patients, including those with end-stage renal disease (ESRD). Mapping and analysis of pericoronary FAI involved three major proximal coronary arteries. The prognostic value of pericoronary FAI for long-term mortality was assessed with multivariable Cox regression models. Results Among 268 CKD participants who underwent coronary CTA, 209 participants with left anterior descending artery (LAD) FAI measurements were included. The pericoronary FAI measured at the LAD was not significantly associated with adjusted risk of all-cause mortality (hazard ratio [HR], 2.08; 95% confidence interval [CI], 0.94–3.51) in any CKD group. However, ESRD patients with elevated pericoronary FAI values had a greater adjusted risk of all-cause mortality compared with the low-FAI group (HR, 2.26; 95% CI, 1.11–4.61). Conclusion The pericoronary FAI measured at the LAD predicted long-term mortality in patients with ESRD, which could provide an opportunity for early primary intervention in ESRD patients. |
| first_indexed | 2024-04-12T08:32:29Z |
| format | Article |
| id | doaj.art-f27bc735682b488db1209b643420bb7d |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-04-12T08:32:29Z |
| publishDate | 2022-01-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-f27bc735682b488db1209b643420bb7d2022-12-22T03:40:11ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402022-01-01411667610.23876/j.krcp.21.0906082Pericoronary fat attenuation index in computed tomography angiography is associated with mortality in end-stage renal diseaseNam-Jun Cho0Bo Da Nam1Samel Park2Hyoungnae Kim3Hyunjin Noh4Jin Seok Jeon5Dong Cheol Han6Eun Young Lee7Hyo-Wook Gil8Soon Hyo Kwon9 Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea Department of Radiology, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of KoreaBackground An increased pericoronary fat attenuation index (FAI) on computed tomography angiography (CTA) is associated with increased all-cause and cardiac mortality in the general population. However, the ability of pericoronary FAI to predict long-term outcomes in chronic kidney disease (CKD) patients is unknown. Methods In this single-center retrospective longitudinal cohort study, we assessed the utility of CTA-based pericoronary FAI measurement to predict mortality of CKD patients, including those with end-stage renal disease (ESRD). Mapping and analysis of pericoronary FAI involved three major proximal coronary arteries. The prognostic value of pericoronary FAI for long-term mortality was assessed with multivariable Cox regression models. Results Among 268 CKD participants who underwent coronary CTA, 209 participants with left anterior descending artery (LAD) FAI measurements were included. The pericoronary FAI measured at the LAD was not significantly associated with adjusted risk of all-cause mortality (hazard ratio [HR], 2.08; 95% confidence interval [CI], 0.94–3.51) in any CKD group. However, ESRD patients with elevated pericoronary FAI values had a greater adjusted risk of all-cause mortality compared with the low-FAI group (HR, 2.26; 95% CI, 1.11–4.61). Conclusion The pericoronary FAI measured at the LAD predicted long-term mortality in patients with ESRD, which could provide an opportunity for early primary intervention in ESRD patients.http://www.krcp-ksn.org/upload/pdf/j-krcp-21-090.pdfchronic kidney diseasecoronary inflammationend-stage renal diseasemortality |
| spellingShingle | Nam-Jun Cho Bo Da Nam Samel Park Hyoungnae Kim Hyunjin Noh Jin Seok Jeon Dong Cheol Han Eun Young Lee Hyo-Wook Gil Soon Hyo Kwon Pericoronary fat attenuation index in computed tomography angiography is associated with mortality in end-stage renal disease Kidney Research and Clinical Practice chronic kidney disease coronary inflammation end-stage renal disease mortality |
| title | Pericoronary fat attenuation index in computed tomography angiography is associated with mortality in end-stage renal disease |
| title_full | Pericoronary fat attenuation index in computed tomography angiography is associated with mortality in end-stage renal disease |
| title_fullStr | Pericoronary fat attenuation index in computed tomography angiography is associated with mortality in end-stage renal disease |
| title_full_unstemmed | Pericoronary fat attenuation index in computed tomography angiography is associated with mortality in end-stage renal disease |
| title_short | Pericoronary fat attenuation index in computed tomography angiography is associated with mortality in end-stage renal disease |
| title_sort | pericoronary fat attenuation index in computed tomography angiography is associated with mortality in end stage renal disease |
| topic | chronic kidney disease coronary inflammation end-stage renal disease mortality |
| url | http://www.krcp-ksn.org/upload/pdf/j-krcp-21-090.pdf |
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