Functional Polymer Nanocarriers for Photodynamic Therapy
Photodynamic therapy (PDT) is an appealing therapeutic modality in management of some solid tumors and other diseases for its minimal invasion and non-systemic toxicity. However, the hydrophobicity and non-selectivity of the photosensitizers, inherent serious hypoxia of tumor tissues and limited pen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/11/4/133 |
| _version_ | 1828869130877403136 |
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| author | Tuanwei Li Lifeng Yan |
| author_facet | Tuanwei Li Lifeng Yan |
| author_sort | Tuanwei Li |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is an appealing therapeutic modality in management of some solid tumors and other diseases for its minimal invasion and non-systemic toxicity. However, the hydrophobicity and non-selectivity of the photosensitizers, inherent serious hypoxia of tumor tissues and limited penetration depth of light restrict PDT further applications in clinic. Functional polymer nanoparticles can be used as a nanocarrier for accurate PDT. Here, we elucidate the mechanism and application of PDT in cancer treatments, and then review some strategies to administer the biodistribution and activation of photosensitizers (PSs) to ameliorate or utilize the tumor hypoxic microenvironment to enhance the photodynamic therapy effect. |
| first_indexed | 2024-12-13T05:44:52Z |
| format | Article |
| id | doaj.art-f27ebec249bd49e7a03d26454de70807 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-13T05:44:52Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-f27ebec249bd49e7a03d26454de708072022-12-21T23:57:42ZengMDPI AGPharmaceuticals1424-82472018-11-0111413310.3390/ph11040133ph11040133Functional Polymer Nanocarriers for Photodynamic TherapyTuanwei Li0Lifeng Yan1CAS Key Laboratory of Soft Matter Chemistry, iChEM, and Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, ChinaCAS Key Laboratory of Soft Matter Chemistry, iChEM, and Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, ChinaPhotodynamic therapy (PDT) is an appealing therapeutic modality in management of some solid tumors and other diseases for its minimal invasion and non-systemic toxicity. However, the hydrophobicity and non-selectivity of the photosensitizers, inherent serious hypoxia of tumor tissues and limited penetration depth of light restrict PDT further applications in clinic. Functional polymer nanoparticles can be used as a nanocarrier for accurate PDT. Here, we elucidate the mechanism and application of PDT in cancer treatments, and then review some strategies to administer the biodistribution and activation of photosensitizers (PSs) to ameliorate or utilize the tumor hypoxic microenvironment to enhance the photodynamic therapy effect.https://www.mdpi.com/1424-8247/11/4/133photodynamic therapynanocarriersphotosensitizershypoxia |
| spellingShingle | Tuanwei Li Lifeng Yan Functional Polymer Nanocarriers for Photodynamic Therapy Pharmaceuticals photodynamic therapy nanocarriers photosensitizers hypoxia |
| title | Functional Polymer Nanocarriers for Photodynamic Therapy |
| title_full | Functional Polymer Nanocarriers for Photodynamic Therapy |
| title_fullStr | Functional Polymer Nanocarriers for Photodynamic Therapy |
| title_full_unstemmed | Functional Polymer Nanocarriers for Photodynamic Therapy |
| title_short | Functional Polymer Nanocarriers for Photodynamic Therapy |
| title_sort | functional polymer nanocarriers for photodynamic therapy |
| topic | photodynamic therapy nanocarriers photosensitizers hypoxia |
| url | https://www.mdpi.com/1424-8247/11/4/133 |
| work_keys_str_mv | AT tuanweili functionalpolymernanocarriersforphotodynamictherapy AT lifengyan functionalpolymernanocarriersforphotodynamictherapy |