Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy
Summary: Patients with the sleep disorder narcolepsy suffer from excessive daytime sleepiness, disrupted nighttime sleep, and cataplexy—the abrupt loss of postural muscle tone during wakefulness, often triggered by strong emotion. The dopamine (DA) system is implicated in both sleep-wake states and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223016905 |
| _version_ | 1797737322536501248 |
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| author | Brandon A. Toth Katie S. Chang Sarah Fechtali Christian R. Burgess |
| author_facet | Brandon A. Toth Katie S. Chang Sarah Fechtali Christian R. Burgess |
| author_sort | Brandon A. Toth |
| collection | DOAJ |
| description | Summary: Patients with the sleep disorder narcolepsy suffer from excessive daytime sleepiness, disrupted nighttime sleep, and cataplexy—the abrupt loss of postural muscle tone during wakefulness, often triggered by strong emotion. The dopamine (DA) system is implicated in both sleep-wake states and cataplexy, but little is known about the function of DA release in the striatum and sleep disorders. Recording DA release in the ventral striatum revealed orexin-independent changes across sleep-wake states as well as striking increases in DA release in the ventral, but not dorsal, striatum prior to cataplexy onset. Tonic low-frequency stimulation of ventral tegmental efferents in the ventral striatum suppressed both cataplexy and rapid eye movement (REM) sleep, while phasic high-frequency stimulation increased cataplexy propensity and decreased the latency to REM sleep. Together, our findings demonstrate a functional role of DA release in the striatum in regulating cataplexy and REM sleep. |
| first_indexed | 2024-03-12T13:28:00Z |
| format | Article |
| id | doaj.art-f27f24010e4443e0af31613849c4810b |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T13:28:00Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-f27f24010e4443e0af31613849c4810b2023-08-25T04:24:40ZengElsevieriScience2589-00422023-09-01269107613Dopamine release in the nucleus accumbens promotes REM sleep and cataplexyBrandon A. Toth0Katie S. Chang1Sarah Fechtali2Christian R. Burgess3Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USAMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USADepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USAMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Corresponding authorSummary: Patients with the sleep disorder narcolepsy suffer from excessive daytime sleepiness, disrupted nighttime sleep, and cataplexy—the abrupt loss of postural muscle tone during wakefulness, often triggered by strong emotion. The dopamine (DA) system is implicated in both sleep-wake states and cataplexy, but little is known about the function of DA release in the striatum and sleep disorders. Recording DA release in the ventral striatum revealed orexin-independent changes across sleep-wake states as well as striking increases in DA release in the ventral, but not dorsal, striatum prior to cataplexy onset. Tonic low-frequency stimulation of ventral tegmental efferents in the ventral striatum suppressed both cataplexy and rapid eye movement (REM) sleep, while phasic high-frequency stimulation increased cataplexy propensity and decreased the latency to REM sleep. Together, our findings demonstrate a functional role of DA release in the striatum in regulating cataplexy and REM sleep.http://www.sciencedirect.com/science/article/pii/S2589004223016905Health sciencesBiological process |
| spellingShingle | Brandon A. Toth Katie S. Chang Sarah Fechtali Christian R. Burgess Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy iScience Health sciences Biological process |
| title | Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy |
| title_full | Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy |
| title_fullStr | Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy |
| title_full_unstemmed | Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy |
| title_short | Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy |
| title_sort | dopamine release in the nucleus accumbens promotes rem sleep and cataplexy |
| topic | Health sciences Biological process |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223016905 |
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