Viral Phrenology
We introduce Viral Phrenology, a new scheme for understanding the genomic composition of spherical viruses based on the locations of their structural protrusions. We used icosahedral point arrays to classify 135 distinct viral capsids collected from over 600 capsids available in the VIPERdb. Using g...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/11/2191 |
| _version_ | 1797508236936478720 |
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| author | David P. Wilson Danielle A. Roof |
| author_facet | David P. Wilson Danielle A. Roof |
| author_sort | David P. Wilson |
| collection | DOAJ |
| description | We introduce Viral Phrenology, a new scheme for understanding the genomic composition of spherical viruses based on the locations of their structural protrusions. We used icosahedral point arrays to classify 135 distinct viral capsids collected from over 600 capsids available in the VIPERdb. Using gauge points of point arrays, we found 149 unique structural protrusions. We then show how to use the locations of these protrusions to determine the genetic composition of the virus. We then show that ssDNA, dsDNA, dsRNA and ssRNA viruses use different arrangements for distributing their protrusions. We also found that Triangulation number is also partially dependent on the structural protrusions. This analysis begins to tie together Baltimore Classification and Triangulation number using point arrays. |
| first_indexed | 2024-03-10T04:59:41Z |
| format | Article |
| id | doaj.art-f27fa9b895c948639c06933902b4ca7d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T04:59:41Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f27fa9b895c948639c06933902b4ca7d2023-11-23T01:56:28ZengMDPI AGViruses1999-49152021-10-011311219110.3390/v13112191Viral PhrenologyDavid P. Wilson0Danielle A. Roof1Department of Physics, Kalamazoo College, Kalamazoo, MI 49006, USADepartment of Physics, Kalamazoo College, Kalamazoo, MI 49006, USAWe introduce Viral Phrenology, a new scheme for understanding the genomic composition of spherical viruses based on the locations of their structural protrusions. We used icosahedral point arrays to classify 135 distinct viral capsids collected from over 600 capsids available in the VIPERdb. Using gauge points of point arrays, we found 149 unique structural protrusions. We then show how to use the locations of these protrusions to determine the genetic composition of the virus. We then show that ssDNA, dsDNA, dsRNA and ssRNA viruses use different arrangements for distributing their protrusions. We also found that Triangulation number is also partially dependent on the structural protrusions. This analysis begins to tie together Baltimore Classification and Triangulation number using point arrays.https://www.mdpi.com/1999-4915/13/11/2191Baltimore Classificationvirus genomeTriangulation numberprotruding featuresspherical viruspoint arrays |
| spellingShingle | David P. Wilson Danielle A. Roof Viral Phrenology Viruses Baltimore Classification virus genome Triangulation number protruding features spherical virus point arrays |
| title | Viral Phrenology |
| title_full | Viral Phrenology |
| title_fullStr | Viral Phrenology |
| title_full_unstemmed | Viral Phrenology |
| title_short | Viral Phrenology |
| title_sort | viral phrenology |
| topic | Baltimore Classification virus genome Triangulation number protruding features spherical virus point arrays |
| url | https://www.mdpi.com/1999-4915/13/11/2191 |
| work_keys_str_mv | AT davidpwilson viralphrenology AT daniellearoof viralphrenology |