Radiation induces ESCRT pathway dependent CD44v3+ extracellular vesicle production stimulating pro-tumor fibroblast activity in breast cancer

Radiation induces ESCRT pathway dependent CD44v3+ extracellular vesicle production stimulating pro-tumor fibroblast activity in breast cancer

Despite recent advances in radiotherapeutic strategies, acquired resistance remains a major obstacle, leading to tumor recurrence for many patients. Once thought to be a strictly cancer cell intrinsic property, it is becoming increasingly clear that treatment-resistance is driven in part by complex...

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Bibliographic Details
Main Authors: Gene Chatman Clark, James David Hampton, Jennifer E. Koblinski, Bridget Quinn, Sitara Mahmoodi, Olga Metcalf, Chunqing Guo, Erica Peterson, Paul B. Fisher, Nicholas P. Farrell, Xiang-Yang Wang, Ross B. Mikkelsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
cancer associated fibroblasts (CAF)
cancer stem cell (CSC)
extracurricular vesicles (EVs)
radiotherapy
radioresistance
ESCRT pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.913656/full

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