Characterization of antihypertensive and cardioprotective effects of extra virgin olive oil against doxorubicin induced cardiomyopathy in rats
Context: The medicinal uses of olive fruit oil (Olea europaea) are clearly documented as an anti-inflammatory, anti-diabetic (type-2 DM), and to protect against heart diseases. Aims: To evaluate the therapeutic influence of extra virgin olive oil (EVOO) as an antihypertensive and cardioprotective...
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| Format: | Article |
| Language: | English |
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GarVal Editorial Ltda.
2020-07-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | http://jppres.com/jppres/pdf/vol8/jppres20.796_8.4.316.pdf |
| _version_ | 1819048509110747136 |
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| author | Waleed Hassan AlMalki Imran Shahid |
| author_facet | Waleed Hassan AlMalki Imran Shahid |
| author_sort | Waleed Hassan AlMalki |
| collection | DOAJ |
| description | Context: The medicinal uses of olive fruit oil (Olea europaea) are clearly documented as an anti-inflammatory, anti-diabetic (type-2 DM), and to protect against heart diseases.
Aims: To evaluate the therapeutic influence of extra virgin olive oil (EVOO) as an antihypertensive and cardioprotective against doxorubicin (DXR) induced cardiomyopathy in rats.
Methods: Wistar rats were divided into five groups as group 1 (normal control), group 2 (disease control i.e., DXR-treated) and groups 3, 4 and 5 as therapeutic groups (i.e., DXR- treated rats plus 2.5%, 5%, and 10% EVOO in diet respectively). Cardiac injury was induced by the administration of DXR. Cardioprotective, anti-hypertensive and antioxidant potential of EVOO were studied by measuring different blood, serum, and tissue biomarkers, enzymes and hemodynamic parameters in disease control and experimental rat groups.
Results: Hemodynamic parameters were significantly reduced in rats administered with 2.5%, 5%, and 10% EVOO as compared to group 2 rats at p<0.05, p<0.01, and p<0.001 respectively. Serum levels of creatinine kinase, troponin T, CK-MB and LDH were found markedly reduced in rats fed with 10% dietary EVOO as compared to disease control rats (p<0.01). Serum levels of antioxidant enzymes like GSH and SOD were found significantly higher in group 5 rats as compared to group 2 at p<0.01, and p<0.001, respectively.
Conclusions: Dietary administration of EVOO has the potential to reduce drug-induced cardiomyopathies and sustained use of EVOO in diet could be cardioprotective and useful against high blood pressure. |
| first_indexed | 2024-12-21T11:17:23Z |
| format | Article |
| id | doaj.art-f282610985c24163bfa35ddcff2d9283 |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-12-21T11:17:23Z |
| publishDate | 2020-07-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-f282610985c24163bfa35ddcff2d92832022-12-21T19:05:53ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502020-07-0184316326Characterization of antihypertensive and cardioprotective effects of extra virgin olive oil against doxorubicin induced cardiomyopathy in ratsWaleed Hassan AlMalki0Imran Shahid1https://orcid.org/0000-0002-9832-3224Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al Qura University, Al-Abidiyah, Makkah, P.O Box. 13578, Postal code 21955, Saudi Arabia.Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al Qura University, Al-Abidiyah, Makkah, P.O Box. 13578, Postal code 21955, Saudi Arabia.Context: The medicinal uses of olive fruit oil (Olea europaea) are clearly documented as an anti-inflammatory, anti-diabetic (type-2 DM), and to protect against heart diseases. Aims: To evaluate the therapeutic influence of extra virgin olive oil (EVOO) as an antihypertensive and cardioprotective against doxorubicin (DXR) induced cardiomyopathy in rats. Methods: Wistar rats were divided into five groups as group 1 (normal control), group 2 (disease control i.e., DXR-treated) and groups 3, 4 and 5 as therapeutic groups (i.e., DXR- treated rats plus 2.5%, 5%, and 10% EVOO in diet respectively). Cardiac injury was induced by the administration of DXR. Cardioprotective, anti-hypertensive and antioxidant potential of EVOO were studied by measuring different blood, serum, and tissue biomarkers, enzymes and hemodynamic parameters in disease control and experimental rat groups. Results: Hemodynamic parameters were significantly reduced in rats administered with 2.5%, 5%, and 10% EVOO as compared to group 2 rats at p<0.05, p<0.01, and p<0.001 respectively. Serum levels of creatinine kinase, troponin T, CK-MB and LDH were found markedly reduced in rats fed with 10% dietary EVOO as compared to disease control rats (p<0.01). Serum levels of antioxidant enzymes like GSH and SOD were found significantly higher in group 5 rats as compared to group 2 at p<0.01, and p<0.001, respectively. Conclusions: Dietary administration of EVOO has the potential to reduce drug-induced cardiomyopathies and sustained use of EVOO in diet could be cardioprotective and useful against high blood pressure.http://jppres.com/jppres/pdf/vol8/jppres20.796_8.4.316.pdfantihyperlipidemicblood pressurecardiac diseasesdrug-induced cardiac injurymonounsaturated fatty acids |
| spellingShingle | Waleed Hassan AlMalki Imran Shahid Characterization of antihypertensive and cardioprotective effects of extra virgin olive oil against doxorubicin induced cardiomyopathy in rats Journal of Pharmacy & Pharmacognosy Research antihyperlipidemic blood pressure cardiac diseases drug-induced cardiac injury monounsaturated fatty acids |
| title | Characterization of antihypertensive and cardioprotective effects of extra virgin olive oil against doxorubicin induced cardiomyopathy in rats |
| title_full | Characterization of antihypertensive and cardioprotective effects of extra virgin olive oil against doxorubicin induced cardiomyopathy in rats |
| title_fullStr | Characterization of antihypertensive and cardioprotective effects of extra virgin olive oil against doxorubicin induced cardiomyopathy in rats |
| title_full_unstemmed | Characterization of antihypertensive and cardioprotective effects of extra virgin olive oil against doxorubicin induced cardiomyopathy in rats |
| title_short | Characterization of antihypertensive and cardioprotective effects of extra virgin olive oil against doxorubicin induced cardiomyopathy in rats |
| title_sort | characterization of antihypertensive and cardioprotective effects of extra virgin olive oil against doxorubicin induced cardiomyopathy in rats |
| topic | antihyperlipidemic blood pressure cardiac diseases drug-induced cardiac injury monounsaturated fatty acids |
| url | http://jppres.com/jppres/pdf/vol8/jppres20.796_8.4.316.pdf |
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