Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity

Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity

Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes. However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying...

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Bibliographic Details
Main Authors: Ghoncheh Mashayekhi, John Vant, Abhigna Polavarapu, Abbas Ourmazd, Abhishek Singharoy
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Structural Biology
Subjects:
Cryo-EM
Molecular dynamics
Free energy landscape
Manifold machine learning
Spike protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X22000034

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