Exposure to metal mixtures and young children’s growth and development: A biomonitoring-based study in Eastern China
Exposure to metal mixtures may affect children's health but the conclusions are controversial. We aimed to investigate the associations of metal mixture exposure with children’s physical and behavioral development. 15 metals were detected in the urine samples of 278 preschoolers aged 3–6 years...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323012307 |
| _version_ | 1797435827791331328 |
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| author | Jiehua Ma Shijie Geng Qi Sun Xu Zhang Linxue Han Xiaodie Yao Biqin Zhang Lijun Zhu Juan Wen |
| author_facet | Jiehua Ma Shijie Geng Qi Sun Xu Zhang Linxue Han Xiaodie Yao Biqin Zhang Lijun Zhu Juan Wen |
| author_sort | Jiehua Ma |
| collection | DOAJ |
| description | Exposure to metal mixtures may affect children's health but the conclusions are controversial. We aimed to investigate the associations of metal mixture exposure with children’s physical and behavioral development. 15 metals were detected in the urine samples of 278 preschoolers aged 3–6 years from eastern China. Multiple linear models and restricted cubic splines were used to evaluate dose-response relationships between single metal and children’s physical and behavioral development. The Bayesian Kernel Machine Regression (BKMR) models, the weighted quantile sum (WQS) models and Quantile G-Computation were applied to evaluate the joint effects of metal mixtures. The results showed that arsenic (As) was negatively associated with z score of height for age (HAZ) in individual-metal models [β (95%CI): − 0.22 (−0.38, −0.06), P = 0.006]. Concerning children’s behavioral development, multiple-metal models demonstrated a negative association with strontium (Sr) [β (95%CI): − 0.82 (−1.38, −0.26), P = 0.004], and a positive association with tin (Sn) [β (95%CI): 0.69 (0.16, 1.21), P = 0.010]. Notably, these associations remained significant or suggestive even after adjustments for multiple tests, sensitivity analyses, and application of different statistical models, including BKMR, WQS, and Quantile G-Computation. Furthermore, the study identified a negative joint effect of the metal mixture on HAZ, as demonstrated by BKMR and Quantile G-Computation models, with As playing an irreplaceable role in this observed impact. In summary, exposure to As appears to have adverse effects on HAZ, while exposure to Sn may hinder children’s behavioral development. Conversely, exposure to Sr may have a protective effect on children’s behavioral development. Additionally, the combined impact of metal mixtures is implicated in potentially impairing children’s physical development, particularly in terms of HAZ. |
| first_indexed | 2024-03-09T10:53:52Z |
| format | Article |
| id | doaj.art-f284453a10f64e8cad38bfc70fea5b3e |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-09T10:53:52Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-f284453a10f64e8cad38bfc70fea5b3e2023-12-01T05:00:36ZengElsevierEcotoxicology and Environmental Safety0147-65132023-12-01268115726Exposure to metal mixtures and young children’s growth and development: A biomonitoring-based study in Eastern ChinaJiehua Ma0Shijie Geng1Qi Sun2Xu Zhang3Linxue Han4Xiaodie Yao5Biqin Zhang6Lijun Zhu7Juan Wen8Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, ChinaNanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, Jiangsu, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaNanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, Jiangsu, ChinaDumeng Kindergarten of Suzhou High-tech Zone, Suzhou 215011, Jiangsu, ChinaNanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, Jiangsu, ChinaNanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, Jiangsu, China; Corresponding author.Exposure to metal mixtures may affect children's health but the conclusions are controversial. We aimed to investigate the associations of metal mixture exposure with children’s physical and behavioral development. 15 metals were detected in the urine samples of 278 preschoolers aged 3–6 years from eastern China. Multiple linear models and restricted cubic splines were used to evaluate dose-response relationships between single metal and children’s physical and behavioral development. The Bayesian Kernel Machine Regression (BKMR) models, the weighted quantile sum (WQS) models and Quantile G-Computation were applied to evaluate the joint effects of metal mixtures. The results showed that arsenic (As) was negatively associated with z score of height for age (HAZ) in individual-metal models [β (95%CI): − 0.22 (−0.38, −0.06), P = 0.006]. Concerning children’s behavioral development, multiple-metal models demonstrated a negative association with strontium (Sr) [β (95%CI): − 0.82 (−1.38, −0.26), P = 0.004], and a positive association with tin (Sn) [β (95%CI): 0.69 (0.16, 1.21), P = 0.010]. Notably, these associations remained significant or suggestive even after adjustments for multiple tests, sensitivity analyses, and application of different statistical models, including BKMR, WQS, and Quantile G-Computation. Furthermore, the study identified a negative joint effect of the metal mixture on HAZ, as demonstrated by BKMR and Quantile G-Computation models, with As playing an irreplaceable role in this observed impact. In summary, exposure to As appears to have adverse effects on HAZ, while exposure to Sn may hinder children’s behavioral development. Conversely, exposure to Sr may have a protective effect on children’s behavioral development. Additionally, the combined impact of metal mixtures is implicated in potentially impairing children’s physical development, particularly in terms of HAZ.http://www.sciencedirect.com/science/article/pii/S0147651323012307Metal mixturesYoung childrenGrowthDevelopmentEastern China |
| spellingShingle | Jiehua Ma Shijie Geng Qi Sun Xu Zhang Linxue Han Xiaodie Yao Biqin Zhang Lijun Zhu Juan Wen Exposure to metal mixtures and young children’s growth and development: A biomonitoring-based study in Eastern China Ecotoxicology and Environmental Safety Metal mixtures Young children Growth Development Eastern China |
| title | Exposure to metal mixtures and young children’s growth and development: A biomonitoring-based study in Eastern China |
| title_full | Exposure to metal mixtures and young children’s growth and development: A biomonitoring-based study in Eastern China |
| title_fullStr | Exposure to metal mixtures and young children’s growth and development: A biomonitoring-based study in Eastern China |
| title_full_unstemmed | Exposure to metal mixtures and young children’s growth and development: A biomonitoring-based study in Eastern China |
| title_short | Exposure to metal mixtures and young children’s growth and development: A biomonitoring-based study in Eastern China |
| title_sort | exposure to metal mixtures and young children s growth and development a biomonitoring based study in eastern china |
| topic | Metal mixtures Young children Growth Development Eastern China |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323012307 |
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