Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency

Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency

Mice with targeted deletion of the GABA catabolic enzyme succinic semialdehyde dehydrogenase (SSADH) manifest lethal tonic–clonic seizures, amenable to pharmacologic rescue, at 3–4 weeks of life. In the current report, we characterized amino acid profiles in SSADH−/− brain utilizing whole brain and...

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Bibliographic Details
Main Authors:	M Gupta, M Polinsky, H Senephansiri, O.C Snead, E.E.W Jansen, C Jakobs, K.M Gibson
Format:	Article
Language:	English
Published:	Elsevier 2004-08-01
Series:	Neurobiology of Disease
Subjects:	Epilepsy GABA Gamma-hydroxybutyric acid Glutamine Succinic semialdehyde dehydrogenase deficiency Knockout
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996104000981

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