Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis
Introduction: Epidemiological studies investigating the association of angiotensin-converting enzyme ( ACE ) gene insertion/deletion (I/D) polymorphism with polycystic ovary syndrome (PCOS) produced inconsistent results. To derive a more precise estimation of the relationship between I/D polymorphis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2013-09-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320312452768 |
| _version_ | 1797285092463214592 |
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| author | Hongxia Jia Bin Wang Lili Yu Zhaoshun Jiang |
| author_facet | Hongxia Jia Bin Wang Lili Yu Zhaoshun Jiang |
| author_sort | Hongxia Jia |
| collection | DOAJ |
| description | Introduction: Epidemiological studies investigating the association of angiotensin-converting enzyme ( ACE ) gene insertion/deletion (I/D) polymorphism with polycystic ovary syndrome (PCOS) produced inconsistent results. To derive a more precise estimation of the relationship between I/D polymorphism and PCOS, we conducted the current meta-analysis. Materials and methods: PubMed, Web of Science and CNKI were searched for eligible publications up to 1 February 2012. The association was evaluated under different genetic models. Results: Six studies with 1451 cases and 773 controls were finally included in our meta-analysis. The results showed that no significant association between I/D polymorphism and PCOS was observed in the overall population. However, in subgroup analyses stratified by ethnicity, significant association was observed in Caucasians (OR = 1.48, 95% CI, 1.00–2.19 for D vs. I; OR = 1.61, 95% CI, 1.14–2.27 for DD vs. II; OR = 1.43, 95% CI, 1.04–1.97 for DD and DI vs. II), but not in Asians. Conclusions: Our meta-analysis suggested that the ACE I/D polymorphism was associated with increased risk of PCOS in Caucasians, but not in Asians. However, considering that the conclusions were based on a relatively small sample size, larger studies involving various ethnic populations should be warranted in future studies to validate our findings. |
| first_indexed | 2024-03-07T17:57:16Z |
| format | Article |
| id | doaj.art-f284d55fd92643328d1204b3118c19f9 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:57:16Z |
| publishDate | 2013-09-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-f284d55fd92643328d1204b3118c19f92024-03-02T11:47:40ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762013-09-011410.1177/1470320312452768Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysisHongxia Jia0Bin Wang1Lili Yu2Zhaoshun Jiang3Department of Endocrinology and Metabolism, The General Hospital of Jinan Military Command, ChinaDepartment of Health Care, Jinan Central Hospital Affiliated to Shandong University, ChinaDepartment of Information Technology, The General Hospital of Jinan Military Command, ChinaDepartment of Endocrinology and Metabolism, The General Hospital of Jinan Military Command, ChinaIntroduction: Epidemiological studies investigating the association of angiotensin-converting enzyme ( ACE ) gene insertion/deletion (I/D) polymorphism with polycystic ovary syndrome (PCOS) produced inconsistent results. To derive a more precise estimation of the relationship between I/D polymorphism and PCOS, we conducted the current meta-analysis. Materials and methods: PubMed, Web of Science and CNKI were searched for eligible publications up to 1 February 2012. The association was evaluated under different genetic models. Results: Six studies with 1451 cases and 773 controls were finally included in our meta-analysis. The results showed that no significant association between I/D polymorphism and PCOS was observed in the overall population. However, in subgroup analyses stratified by ethnicity, significant association was observed in Caucasians (OR = 1.48, 95% CI, 1.00–2.19 for D vs. I; OR = 1.61, 95% CI, 1.14–2.27 for DD vs. II; OR = 1.43, 95% CI, 1.04–1.97 for DD and DI vs. II), but not in Asians. Conclusions: Our meta-analysis suggested that the ACE I/D polymorphism was associated with increased risk of PCOS in Caucasians, but not in Asians. However, considering that the conclusions were based on a relatively small sample size, larger studies involving various ethnic populations should be warranted in future studies to validate our findings.https://doi.org/10.1177/1470320312452768 |
| spellingShingle | Hongxia Jia Bin Wang Lili Yu Zhaoshun Jiang Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
| title | Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis |
| title_full | Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis |
| title_fullStr | Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis |
| title_full_unstemmed | Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis |
| title_short | Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis |
| title_sort | association of angiotensin converting enzyme gene insertion deletion polymorphism with polycystic ovary syndrome a meta analysis |
| url | https://doi.org/10.1177/1470320312452768 |
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