Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications
Type 2 diabetes mellitus (T2DM) still holds the title as one of the most debilitating chronic diseases with rising prevalence and incidence, including its complications such as retinal, renal, and peripheral nerve disease. In order to develop novel molecules for diagnosis and treatment, a deep under...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/18/6053 |
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| author | Daniela Maria Tanase Evelina Maria Gosav Tina Botoc Mariana Floria Claudia Cristina Tarniceriu Minela Aida Maranduca Anca Haisan Andrei Ionut Cucu Ciprian Rezus Claudia Florida Costea |
| author_facet | Daniela Maria Tanase Evelina Maria Gosav Tina Botoc Mariana Floria Claudia Cristina Tarniceriu Minela Aida Maranduca Anca Haisan Andrei Ionut Cucu Ciprian Rezus Claudia Florida Costea |
| author_sort | Daniela Maria Tanase |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) still holds the title as one of the most debilitating chronic diseases with rising prevalence and incidence, including its complications such as retinal, renal, and peripheral nerve disease. In order to develop novel molecules for diagnosis and treatment, a deep understanding of the complex molecular pathways is imperative. Currently, the existing agents for T2DM treatment target only blood glucose levels. Over the past decades, specific building blocks of proteins—branched-chain amino acids (BCAAs) including leucine, isoleucine, and valine—have gained attention because they are linked with insulin resistance, pre-diabetes, and diabetes development. In this review, we discuss the hypothetical link between BCAA metabolism, insulin resistance, T2DM, and its microvascular complications including diabetic retinopathy and diabetic nephropathy. Further research on these amino acids and their derivates may eventually pave the way to novel biomarkers or therapeutic concepts for the treatment of diabetes and its accompanied complications. |
| first_indexed | 2024-03-10T22:37:44Z |
| format | Article |
| id | doaj.art-f28531441b15467aab7556e0be6f665e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T22:37:44Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f28531441b15467aab7556e0be6f665e2023-11-19T11:21:07ZengMDPI AGJournal of Clinical Medicine2077-03832023-09-011218605310.3390/jcm12186053Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular ComplicationsDaniela Maria Tanase0Evelina Maria Gosav1Tina Botoc2Mariana Floria3Claudia Cristina Tarniceriu4Minela Aida Maranduca5Anca Haisan6Andrei Ionut Cucu7Ciprian Rezus8Claudia Florida Costea9Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Ophthalmology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Morpho-Functional Sciences I, Discipline of Anatomy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaInternal Medicine Clinic, “St. Spiridon” County Clinical Emergency Hospital Iasi, 700111 Iasi, RomaniaDepartment of Emergency Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Biomedical Sciences, Faculty of Medicine and Biological Sciences, “Ștefan cel Mare” University, 720229 Suceava, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Ophthalmology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaType 2 diabetes mellitus (T2DM) still holds the title as one of the most debilitating chronic diseases with rising prevalence and incidence, including its complications such as retinal, renal, and peripheral nerve disease. In order to develop novel molecules for diagnosis and treatment, a deep understanding of the complex molecular pathways is imperative. Currently, the existing agents for T2DM treatment target only blood glucose levels. Over the past decades, specific building blocks of proteins—branched-chain amino acids (BCAAs) including leucine, isoleucine, and valine—have gained attention because they are linked with insulin resistance, pre-diabetes, and diabetes development. In this review, we discuss the hypothetical link between BCAA metabolism, insulin resistance, T2DM, and its microvascular complications including diabetic retinopathy and diabetic nephropathy. Further research on these amino acids and their derivates may eventually pave the way to novel biomarkers or therapeutic concepts for the treatment of diabetes and its accompanied complications.https://www.mdpi.com/2077-0383/12/18/6053diabetes mellitusT2DMbranched chain amino acidsBCAAsdiabetic retinopathydiabetic nephropathy |
| spellingShingle | Daniela Maria Tanase Evelina Maria Gosav Tina Botoc Mariana Floria Claudia Cristina Tarniceriu Minela Aida Maranduca Anca Haisan Andrei Ionut Cucu Ciprian Rezus Claudia Florida Costea Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications Journal of Clinical Medicine diabetes mellitus T2DM branched chain amino acids BCAAs diabetic retinopathy diabetic nephropathy |
| title | Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications |
| title_full | Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications |
| title_fullStr | Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications |
| title_full_unstemmed | Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications |
| title_short | Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications |
| title_sort | depiction of branched chain amino acids bcaas in diabetes with a focus on diabetic microvascular complications |
| topic | diabetes mellitus T2DM branched chain amino acids BCAAs diabetic retinopathy diabetic nephropathy |
| url | https://www.mdpi.com/2077-0383/12/18/6053 |
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