The application of genome-wide CRISPR-Cas9 screens to dissect the molecular mechanisms of toxins

The application of genome-wide CRISPR-Cas9 screens to dissect the molecular mechanisms of toxins

Many toxins are life-threatening to both animals and humans. However, specific antidotes are not available for most of those toxins. The molecular mechanisms underlying the toxicology of well-known toxins are not yet fully characterized. Recently, the advance in CRISPR-Cas9 technologies has greatly...

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Bibliographic Details
Main Authors: Bei Wang, Jun-Zhu Chen, Xue-Qun Luo, Guo-Hui Wan, Yan-Lai Tang, Qiao-Ping Wang
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
CISRPR
Genome-wide
CRISPR-Cas9 screen
GeCKO
Mechanism
Toxin
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022004196

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