Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the intestine. Here, we developed a robust method for rapid, medium...

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Bibliographic Details
Main Authors: Alexandra Teleki, Olivia Nylander, Christel A.S. Bergström
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
intrinsic dissolution rate
biorelevant dissolution media
FaSSIF
FeSSIF
poorly water-soluble drugs
physicochemical properties
Online Access:https://www.mdpi.com/1999-4923/12/6/493

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