Maternal TSH levels at first trimester and subsequent spontaneous miscarriage: a nested case–control study
Thyroid dysfunction is a frequently found endocrine disorder among reproductively aged women. Subclinical hypothyroidism is the most common condition of thyroid disorders during pregnancy and is defined as manifesting a thyro id-stimulating hormone concentration exceeding the trimester-specific refe...
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Bioscientifica
2019-09-01
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| Series: | Endocrine Connections |
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| Online Access: | https://ec.bioscientifica.com/view/journals/ec/8/9/EC-19-0316.xml |
| _version_ | 1818357706492215296 |
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| author | Jiashu Li Aihua Liu Haixia Liu Chenyan Li Weiwei Wang Cheng Han Xinyi Wang Yuanyuan Zhang Weiping Teng Zhongyan Shan |
| author_facet | Jiashu Li Aihua Liu Haixia Liu Chenyan Li Weiwei Wang Cheng Han Xinyi Wang Yuanyuan Zhang Weiping Teng Zhongyan Shan |
| author_sort | Jiashu Li |
| collection | DOAJ |
| description | Thyroid dysfunction is a frequently found endocrine disorder among reproductively aged women. Subclinical hypothyroidism is the most common condition of thyroid disorders during pregnancy and is defined as manifesting a thyro id-stimulating hormone concentration exceeding the trimester-specific reference value, with a normal free thyroxine concentration. Here, we evaluated the prospective association between spontaneous miscarriage and first-trimester thyroid function. We conducted a case–control study (421 cases and 1684 controls) that was nested. Thyroid-st imulating hormone (TSH), free thyroxine (FT4), thyroid-peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) status were measured. We found that higher TSH was relat ed to spontaneous miscarriage (OR 1.21; 95% CI, 1.13–1.30, P < 0.001). Compared with women with TSH levels of 0.4–<2.5 mIU/L, the risk of miscarriage was increased in wom en with TSH levels of 2.5–<4.87 mIU/L (OR 1.47; 95% CI, 1.16–1.87) and TSH greater th an 4.87 mIU/L (OR 1.97; 95% CI, 1.22–3.18). After controlling for the confounding facto r, TPOAb positivity status and FT4, the results were similar. The present study showed that higher TSH was associated with miscarriage in early pregnancy. In fact, TSH levels betwee n 2.5 and 4.87 mIU/L increased the risk for miscarriage, with TSH greater than 4.87 mIU/L increasing the risk even further. |
| first_indexed | 2024-12-13T20:17:22Z |
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| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-13T20:17:22Z |
| publishDate | 2019-09-01 |
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| series | Endocrine Connections |
| spelling | doaj.art-f2876b77afd94716862142f70d6d75cb2022-12-21T23:32:47ZengBioscientificaEndocrine Connections2049-36142049-36142019-09-018912881293https://doi.org/10.1530/EC-19-0316Maternal TSH levels at first trimester and subsequent spontaneous miscarriage: a nested case–control studyJiashu Li0Aihua Liu1Haixia Liu2Chenyan Li3Weiwei Wang4Cheng Han5Xinyi Wang6Yuanyuan Zhang7Weiping Teng8Zhongyan Shan9Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, China; Department of Endocrinology and Metabolism, The Second Hospital of Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, ChinaThyroid dysfunction is a frequently found endocrine disorder among reproductively aged women. Subclinical hypothyroidism is the most common condition of thyroid disorders during pregnancy and is defined as manifesting a thyro id-stimulating hormone concentration exceeding the trimester-specific reference value, with a normal free thyroxine concentration. Here, we evaluated the prospective association between spontaneous miscarriage and first-trimester thyroid function. We conducted a case–control study (421 cases and 1684 controls) that was nested. Thyroid-st imulating hormone (TSH), free thyroxine (FT4), thyroid-peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) status were measured. We found that higher TSH was relat ed to spontaneous miscarriage (OR 1.21; 95% CI, 1.13–1.30, P < 0.001). Compared with women with TSH levels of 0.4–<2.5 mIU/L, the risk of miscarriage was increased in wom en with TSH levels of 2.5–<4.87 mIU/L (OR 1.47; 95% CI, 1.16–1.87) and TSH greater th an 4.87 mIU/L (OR 1.97; 95% CI, 1.22–3.18). After controlling for the confounding facto r, TPOAb positivity status and FT4, the results were similar. The present study showed that higher TSH was associated with miscarriage in early pregnancy. In fact, TSH levels betwee n 2.5 and 4.87 mIU/L increased the risk for miscarriage, with TSH greater than 4.87 mIU/L increasing the risk even further.https://ec.bioscientifica.com/view/journals/ec/8/9/EC-19-0316.xmlthyroidreproduction |
| spellingShingle | Jiashu Li Aihua Liu Haixia Liu Chenyan Li Weiwei Wang Cheng Han Xinyi Wang Yuanyuan Zhang Weiping Teng Zhongyan Shan Maternal TSH levels at first trimester and subsequent spontaneous miscarriage: a nested case–control study Endocrine Connections thyroid reproduction |
| title | Maternal TSH levels at first trimester and subsequent spontaneous miscarriage: a nested case–control study |
| title_full | Maternal TSH levels at first trimester and subsequent spontaneous miscarriage: a nested case–control study |
| title_fullStr | Maternal TSH levels at first trimester and subsequent spontaneous miscarriage: a nested case–control study |
| title_full_unstemmed | Maternal TSH levels at first trimester and subsequent spontaneous miscarriage: a nested case–control study |
| title_short | Maternal TSH levels at first trimester and subsequent spontaneous miscarriage: a nested case–control study |
| title_sort | maternal tsh levels at first trimester and subsequent spontaneous miscarriage a nested case control study |
| topic | thyroid reproduction |
| url | https://ec.bioscientifica.com/view/journals/ec/8/9/EC-19-0316.xml |
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