Synthesis of new dental monomers based on glycidyl methacrylate and their evaluation of cytotoxic and antibacterial activity
In this study, glycidyl methacrylate (GMA)-ciprofloxacin and GMA-ampicillin were successfully synthesized as antibacterial dental monomers. The antibacterial activity of resin composites containing 0–5 wt% GMA-ciprofloxacin and GMA-ampicillin was evaluated by using direct contact tests (DCTs) on the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Polymer Testing |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0142941822003397 |
| _version_ | 1811315932079849472 |
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| author | Mohammad Zarei Iman Mohammadzadeh Ali Derakhshani Kazem Saidi Hassan Sheibani |
| author_facet | Mohammad Zarei Iman Mohammadzadeh Ali Derakhshani Kazem Saidi Hassan Sheibani |
| author_sort | Mohammad Zarei |
| collection | DOAJ |
| description | In this study, glycidyl methacrylate (GMA)-ciprofloxacin and GMA-ampicillin were successfully synthesized as antibacterial dental monomers. The antibacterial activity of resin composites containing 0–5 wt% GMA-ciprofloxacin and GMA-ampicillin was evaluated by using direct contact tests (DCTs) on the cured resins against Streptococcus mutans. After 72 h, the 5 wt% GMA-ciprofloxacin monomer with resin composite showed the highest lethality against Streptococcus mutans. The cytotoxic activity of the synthesized monomers in the concentration range of 5–100 μL mL−1 was investigated against human dental pulp stem cells (DPSCs), and the physical properties of the prepared monomers, such as water sorption, were subsequently assessed. The structure and morphology of the synthesized monomers were characterized using nuclear magnetic resonance (NMR) spectra and field-emission scanning electron microscopy (FE-SEM) techniques. The results revealed that the GMA-ciprofloxacin and GMA-ampicillin monomers were biocompatible at low dosage. The goal of this study was to synthesize new antibacterial monomers and examine their antibacterial properties and cytotoxic activity in dental resin composites. |
| first_indexed | 2024-04-13T11:40:12Z |
| format | Article |
| id | doaj.art-f28828f698394c8ab383b392e6a93fa4 |
| institution | Directory Open Access Journal |
| issn | 0142-9418 |
| language | English |
| last_indexed | 2024-04-13T11:40:12Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Polymer Testing |
| spelling | doaj.art-f28828f698394c8ab383b392e6a93fa42022-12-22T02:48:20ZengElsevierPolymer Testing0142-94182023-01-01117107818Synthesis of new dental monomers based on glycidyl methacrylate and their evaluation of cytotoxic and antibacterial activityMohammad Zarei0Iman Mohammadzadeh1Ali Derakhshani2Kazem Saidi3Hassan Sheibani4Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, 76169, IranEndodontology Research Center, Kerman University of Medical Sciences, Kerman, 76188, Iran; Corresponding author.Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, IranDepartment of Chemistry, Shahid Bahonar University of Kerman, Kerman, 76169, IranDepartment of Chemistry, Shahid Bahonar University of Kerman, Kerman, 76169, Iran; Corresponding author.In this study, glycidyl methacrylate (GMA)-ciprofloxacin and GMA-ampicillin were successfully synthesized as antibacterial dental monomers. The antibacterial activity of resin composites containing 0–5 wt% GMA-ciprofloxacin and GMA-ampicillin was evaluated by using direct contact tests (DCTs) on the cured resins against Streptococcus mutans. After 72 h, the 5 wt% GMA-ciprofloxacin monomer with resin composite showed the highest lethality against Streptococcus mutans. The cytotoxic activity of the synthesized monomers in the concentration range of 5–100 μL mL−1 was investigated against human dental pulp stem cells (DPSCs), and the physical properties of the prepared monomers, such as water sorption, were subsequently assessed. The structure and morphology of the synthesized monomers were characterized using nuclear magnetic resonance (NMR) spectra and field-emission scanning electron microscopy (FE-SEM) techniques. The results revealed that the GMA-ciprofloxacin and GMA-ampicillin monomers were biocompatible at low dosage. The goal of this study was to synthesize new antibacterial monomers and examine their antibacterial properties and cytotoxic activity in dental resin composites.http://www.sciencedirect.com/science/article/pii/S0142941822003397Antibacterial monomersCytotoxic and antibacterial activityStreptococcus mutansDental pulp stem cells |
| spellingShingle | Mohammad Zarei Iman Mohammadzadeh Ali Derakhshani Kazem Saidi Hassan Sheibani Synthesis of new dental monomers based on glycidyl methacrylate and their evaluation of cytotoxic and antibacterial activity Polymer Testing Antibacterial monomers Cytotoxic and antibacterial activity Streptococcus mutans Dental pulp stem cells |
| title | Synthesis of new dental monomers based on glycidyl methacrylate and their evaluation of cytotoxic and antibacterial activity |
| title_full | Synthesis of new dental monomers based on glycidyl methacrylate and their evaluation of cytotoxic and antibacterial activity |
| title_fullStr | Synthesis of new dental monomers based on glycidyl methacrylate and their evaluation of cytotoxic and antibacterial activity |
| title_full_unstemmed | Synthesis of new dental monomers based on glycidyl methacrylate and their evaluation of cytotoxic and antibacterial activity |
| title_short | Synthesis of new dental monomers based on glycidyl methacrylate and their evaluation of cytotoxic and antibacterial activity |
| title_sort | synthesis of new dental monomers based on glycidyl methacrylate and their evaluation of cytotoxic and antibacterial activity |
| topic | Antibacterial monomers Cytotoxic and antibacterial activity Streptococcus mutans Dental pulp stem cells |
| url | http://www.sciencedirect.com/science/article/pii/S0142941822003397 |
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