Analysis of Clinicopathological Features of Cervical Mucinous Adenocarcinoma with a Solitary Ovarian Metastatic Mass as the First Manifestation
Shuanghuan Liu,1 Yunquan Guo,2,3 Bin Li,1 Huijuan Zhang,2 Rong Zhang,1 Shan Zheng2 1Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People&rsquo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/analysis-of-clinicopathological-features-of-cervical-mucinous-adenocar-peer-reviewed-article-CMAR |
| _version_ | 1824014013406642176 |
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| author | Liu S Guo Y Li B Zhang H Zhang R Zheng S |
| author_facet | Liu S Guo Y Li B Zhang H Zhang R Zheng S |
| author_sort | Liu S |
| collection | DOAJ |
| description | Shuanghuan Liu,1 Yunquan Guo,2,3 Bin Li,1 Huijuan Zhang,2 Rong Zhang,1 Shan Zheng2 1Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 2Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Pathology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, People’s Republic of ChinaCorrespondence: Bin LiDepartment of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, South Panjiayuan Residential, Beijing, Chaoyang 100021, People’s Republic of ChinaTel/ Fax +86-10-8778-8275Email libin@cicams.ac.cnShan ZhengDepartment of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, South Panjiayuan Residential, Beijing, Chaoyang 100021, People’s Republic of ChinaTel +86-10-8778-7514Fax +86-10-8771-8709Email zhengshan@cicams.ac.cnPurpose: To avoid misdiagnosis, clinicopathological features were analyzed in cases of cervical mucinous adenocarcinoma with solitary ovarian metastatic masses.Patients and Methods: Three cases misdiagnosed as primary ovarian adenocarcinoma before surgery were filtered from the database of the Cancer Hospital/Chinese Academy of Medical Sciences from January 1998 to December 2016. The clinical data were thoroughly collected and compared, and both frozen and paraffin-embedded pathological sections were reviewed by two expert pathologists.Results: None of the patients experienced cervical contact bleeding, and no typical cervical neoplasms were found. The cervical canals were slightly thickened in two patients, as detected by either palpation or imaging. The high-risk human papillomavirus (HPV) test results were all negative, and the thin-prep cytologic test (TCT) screened only one case of atypical glandular epithelial cells. All cases were indicative of higher serum CA19-9 levels (79.49– 6124 U/mL). The ovarian masses showed no regular laterality, while they were all cystic or solid-cystic. Their pathological sections indicated a benign appearance of the capsule tissue with well-differentiated mucinous glands infiltrating the ovarian cortex with focal necrosis.Conclusion: Attention should be paid to cervical examinations before and during surgery for cervical mucinous adenocarcinoma with a metastatic ovarian mass as the first manifestation. Such patients may gain a better prognosis after active treatment.Keywords: cervical mucinous adenocarcinoma, metastatic ovarian mucinous adenocarcinoma, solitary ovarian metastasis, occult primary lesion, misdiagnosis, clinicopathological feature |
| first_indexed | 2024-12-18T22:08:44Z |
| format | Article |
| id | doaj.art-f28ae775a63148a49757c64ba5a2ea74 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-18T22:08:44Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-f28ae775a63148a49757c64ba5a2ea742022-12-21T20:50:02ZengDove Medical PressCancer Management and Research1179-13222020-09-01Volume 128965897357345Analysis of Clinicopathological Features of Cervical Mucinous Adenocarcinoma with a Solitary Ovarian Metastatic Mass as the First ManifestationLiu SGuo YLi BZhang HZhang RZheng SShuanghuan Liu,1 Yunquan Guo,2,3 Bin Li,1 Huijuan Zhang,2 Rong Zhang,1 Shan Zheng2 1Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 2Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Pathology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, People’s Republic of ChinaCorrespondence: Bin LiDepartment of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, South Panjiayuan Residential, Beijing, Chaoyang 100021, People’s Republic of ChinaTel/ Fax +86-10-8778-8275Email libin@cicams.ac.cnShan ZhengDepartment of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, South Panjiayuan Residential, Beijing, Chaoyang 100021, People’s Republic of ChinaTel +86-10-8778-7514Fax +86-10-8771-8709Email zhengshan@cicams.ac.cnPurpose: To avoid misdiagnosis, clinicopathological features were analyzed in cases of cervical mucinous adenocarcinoma with solitary ovarian metastatic masses.Patients and Methods: Three cases misdiagnosed as primary ovarian adenocarcinoma before surgery were filtered from the database of the Cancer Hospital/Chinese Academy of Medical Sciences from January 1998 to December 2016. The clinical data were thoroughly collected and compared, and both frozen and paraffin-embedded pathological sections were reviewed by two expert pathologists.Results: None of the patients experienced cervical contact bleeding, and no typical cervical neoplasms were found. The cervical canals were slightly thickened in two patients, as detected by either palpation or imaging. The high-risk human papillomavirus (HPV) test results were all negative, and the thin-prep cytologic test (TCT) screened only one case of atypical glandular epithelial cells. All cases were indicative of higher serum CA19-9 levels (79.49– 6124 U/mL). The ovarian masses showed no regular laterality, while they were all cystic or solid-cystic. Their pathological sections indicated a benign appearance of the capsule tissue with well-differentiated mucinous glands infiltrating the ovarian cortex with focal necrosis.Conclusion: Attention should be paid to cervical examinations before and during surgery for cervical mucinous adenocarcinoma with a metastatic ovarian mass as the first manifestation. Such patients may gain a better prognosis after active treatment.Keywords: cervical mucinous adenocarcinoma, metastatic ovarian mucinous adenocarcinoma, solitary ovarian metastasis, occult primary lesion, misdiagnosis, clinicopathological featurehttps://www.dovepress.com/analysis-of-clinicopathological-features-of-cervical-mucinous-adenocar-peer-reviewed-article-CMARcervical mucinous adenocarcinomametastatic ovarian mucinous adenocarcinomasolitary ovarian metastasisoccult primary lesionmisdiagnosisclinicopathological feature |
| spellingShingle | Liu S Guo Y Li B Zhang H Zhang R Zheng S Analysis of Clinicopathological Features of Cervical Mucinous Adenocarcinoma with a Solitary Ovarian Metastatic Mass as the First Manifestation Cancer Management and Research cervical mucinous adenocarcinoma metastatic ovarian mucinous adenocarcinoma solitary ovarian metastasis occult primary lesion misdiagnosis clinicopathological feature |
| title | Analysis of Clinicopathological Features of Cervical Mucinous Adenocarcinoma with a Solitary Ovarian Metastatic Mass as the First Manifestation |
| title_full | Analysis of Clinicopathological Features of Cervical Mucinous Adenocarcinoma with a Solitary Ovarian Metastatic Mass as the First Manifestation |
| title_fullStr | Analysis of Clinicopathological Features of Cervical Mucinous Adenocarcinoma with a Solitary Ovarian Metastatic Mass as the First Manifestation |
| title_full_unstemmed | Analysis of Clinicopathological Features of Cervical Mucinous Adenocarcinoma with a Solitary Ovarian Metastatic Mass as the First Manifestation |
| title_short | Analysis of Clinicopathological Features of Cervical Mucinous Adenocarcinoma with a Solitary Ovarian Metastatic Mass as the First Manifestation |
| title_sort | analysis of clinicopathological features of cervical mucinous adenocarcinoma with a solitary ovarian metastatic mass as the first manifestation |
| topic | cervical mucinous adenocarcinoma metastatic ovarian mucinous adenocarcinoma solitary ovarian metastasis occult primary lesion misdiagnosis clinicopathological feature |
| url | https://www.dovepress.com/analysis-of-clinicopathological-features-of-cervical-mucinous-adenocar-peer-reviewed-article-CMAR |
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