Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score

Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score

Abstract Background Polygenic risk score (PRS) analysis is used to predict disease risk. Although PRS has been shown to have great potential in improving clinical care, PRS accuracy assessment has been mainly focused on European ancestry. This study aimed to develop an accurate genetic risk score fo...

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Bibliographic Details
Main Authors: Yugo Morita, Yoichiro Kamatani, Hiromu Ito, Shiro Ikegawa, Takahisa Kawaguchi, Shuji Kawaguchi, Meiko Takahashi, Chikashi Terao, Shuji Ito, Kohei Nishitani, Shinichiro Nakamura, Shinichi Kuriyama, Yasuharu Tabara, Fumihiko Matsuda, Shuichi Matsuda, on behalf of the Nagahama study group
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Arthritis Research & Therapy
Subjects:
Polygenic risk score
Knee osteoarthritis
Genetics
Multi-population
Multi-traits
Online Access:https://doi.org/10.1186/s13075-023-03082-y

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