Translating evidence into practice: eligibility criteria fail to eliminate clinically significant differences between real-world and study populations
Abstract Randomized controlled trials (RCTs) are regarded as the most reputable source of evidence. In some studies, factors beyond the intervention itself may contribute to the measured effect, an occurrence known as heterogeneity of treatment effect (HTE). If the RCT population differs from the re...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-05-01
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| Series: | npj Digital Medicine |
| Online Access: | https://doi.org/10.1038/s41746-020-0277-8 |