Effect of Amlodipine/Nebivolol combination therapy on central BP and PWV compared to Amlodipine/Valsartan combination therapy
Abstract Background Pulse wave velocity (PWV) and central blood pressure (CBP) have been intoduced into managment of hypertensive patients. PWV is positively correlated with arterial wall stiffness while central aortic pressure becomes better predictor of cardiovascular outcome than peripheral press...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-03-01
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| Series: | The Egyptian Heart Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43044-022-00254-0 |
| _version_ | 1818306328221712384 |
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| author | El-Zahraa M. Sultan Hoda Rabea Ahmed A. Elberry Hesham B. Mahmoud |
| author_facet | El-Zahraa M. Sultan Hoda Rabea Ahmed A. Elberry Hesham B. Mahmoud |
| author_sort | El-Zahraa M. Sultan |
| collection | DOAJ |
| description | Abstract Background Pulse wave velocity (PWV) and central blood pressure (CBP) have been intoduced into managment of hypertensive patients. PWV is positively correlated with arterial wall stiffness while central aortic pressure becomes better predictor of cardiovascular outcome than peripheral pressure. Reduction in CBP provides protective properties against subclinical organ damage. This work aims to investigate the effect of a new combination therapy of Amlodipine/Nebivolol (A/N) on central BP, peripheral BP and PWV. The results of using this combination will be compared to the well-established fixed-dose combination of Amlodipine/Valsartan (A/V). The study conducted between October 2018 and August 2020. One hundred and two hypertensive patients were assigned for Amlodipine 10 mg/Valsartan 160 mg combination therapy (A/V, n = 52) or Amlodipine 10 mg/Nebivolol 5 mg combination therapy (A/N, n = 50) by simple 1:1 randomization. Office, central blood pressure and PWV were measured on first (0 week), second (4–8 weeks) and third visit (10–12). Difference in BP (in each arm and between arms) was calculated along all visits. Results No statistical significant difference was found between A/V and A/N regarding age, gender, BMI and CV history. OBP, CBP and PWV were significantly reduced in each arm, but no differences were found when comparing both arm results to each other. Recorded side effects were insignificant. Conclusions The new combination therapy Amlodipine/Nebivolol (A/N) affords a significant reduction in CBP, PBP and PWV with minor and tolerable side effects. It has provided comparable results to Amlodipine/Valsartan (A/V) combination therapy. |
| first_indexed | 2024-12-13T06:40:44Z |
| format | Article |
| id | doaj.art-f294207a01834cff9c3b3026d74a4032 |
| institution | Directory Open Access Journal |
| issn | 2090-911X |
| language | English |
| last_indexed | 2024-12-13T06:40:44Z |
| publishDate | 2022-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-f294207a01834cff9c3b3026d74a40322022-12-21T23:56:26ZengSpringerOpenThe Egyptian Heart Journal2090-911X2022-03-017411810.1186/s43044-022-00254-0Effect of Amlodipine/Nebivolol combination therapy on central BP and PWV compared to Amlodipine/Valsartan combination therapyEl-Zahraa M. Sultan0Hoda Rabea1Ahmed A. Elberry2Hesham B. Mahmoud3Cardiology Department, Beni-Suef University HospitalClinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef UniversityDepartment of Pharmacy Practice, Pharmacy Program, Batterjee Medical CollegeBeni-Suef University HospitalAbstract Background Pulse wave velocity (PWV) and central blood pressure (CBP) have been intoduced into managment of hypertensive patients. PWV is positively correlated with arterial wall stiffness while central aortic pressure becomes better predictor of cardiovascular outcome than peripheral pressure. Reduction in CBP provides protective properties against subclinical organ damage. This work aims to investigate the effect of a new combination therapy of Amlodipine/Nebivolol (A/N) on central BP, peripheral BP and PWV. The results of using this combination will be compared to the well-established fixed-dose combination of Amlodipine/Valsartan (A/V). The study conducted between October 2018 and August 2020. One hundred and two hypertensive patients were assigned for Amlodipine 10 mg/Valsartan 160 mg combination therapy (A/V, n = 52) or Amlodipine 10 mg/Nebivolol 5 mg combination therapy (A/N, n = 50) by simple 1:1 randomization. Office, central blood pressure and PWV were measured on first (0 week), second (4–8 weeks) and third visit (10–12). Difference in BP (in each arm and between arms) was calculated along all visits. Results No statistical significant difference was found between A/V and A/N regarding age, gender, BMI and CV history. OBP, CBP and PWV were significantly reduced in each arm, but no differences were found when comparing both arm results to each other. Recorded side effects were insignificant. Conclusions The new combination therapy Amlodipine/Nebivolol (A/N) affords a significant reduction in CBP, PBP and PWV with minor and tolerable side effects. It has provided comparable results to Amlodipine/Valsartan (A/V) combination therapy.https://doi.org/10.1186/s43044-022-00254-0Amlodipine/NebivololAmlodipine/ValsartanCombination therapyHypertensionCentral blood pressureArterial stiffness |
| spellingShingle | El-Zahraa M. Sultan Hoda Rabea Ahmed A. Elberry Hesham B. Mahmoud Effect of Amlodipine/Nebivolol combination therapy on central BP and PWV compared to Amlodipine/Valsartan combination therapy The Egyptian Heart Journal Amlodipine/Nebivolol Amlodipine/Valsartan Combination therapy Hypertension Central blood pressure Arterial stiffness |
| title | Effect of Amlodipine/Nebivolol combination therapy on central BP and PWV compared to Amlodipine/Valsartan combination therapy |
| title_full | Effect of Amlodipine/Nebivolol combination therapy on central BP and PWV compared to Amlodipine/Valsartan combination therapy |
| title_fullStr | Effect of Amlodipine/Nebivolol combination therapy on central BP and PWV compared to Amlodipine/Valsartan combination therapy |
| title_full_unstemmed | Effect of Amlodipine/Nebivolol combination therapy on central BP and PWV compared to Amlodipine/Valsartan combination therapy |
| title_short | Effect of Amlodipine/Nebivolol combination therapy on central BP and PWV compared to Amlodipine/Valsartan combination therapy |
| title_sort | effect of amlodipine nebivolol combination therapy on central bp and pwv compared to amlodipine valsartan combination therapy |
| topic | Amlodipine/Nebivolol Amlodipine/Valsartan Combination therapy Hypertension Central blood pressure Arterial stiffness |
| url | https://doi.org/10.1186/s43044-022-00254-0 |
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