Factors associated with recruitment, surveillance participation, and retention in an observational study of pregnant women and influenza
Abstract Background This report describes the results of recruitment efforts and the subsequent participation of pregnant women in study activities in a 2010–2012 observational study focused on influenza illness and vaccination in California and Oregon, USA. Methods Socio-demographic and health char...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | http://link.springer.com/article/10.1186/s12884-019-2280-0 |
| _version_ | 1828385667761045504 |
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| author | Mark G. Thompson De-Kun Li Allison L. Naleway Jeannette R. Ferber Michelle L. Henninger Pat Shifflett Leslie Z. Sokolow Roxana Odouli Tia L. Kauffman Rebecca V. Fink Joanna Bulkley Janet D. Cragan Sam Bozeman |
| author_facet | Mark G. Thompson De-Kun Li Allison L. Naleway Jeannette R. Ferber Michelle L. Henninger Pat Shifflett Leslie Z. Sokolow Roxana Odouli Tia L. Kauffman Rebecca V. Fink Joanna Bulkley Janet D. Cragan Sam Bozeman |
| author_sort | Mark G. Thompson |
| collection | DOAJ |
| description | Abstract Background This report describes the results of recruitment efforts and the subsequent participation of pregnant women in study activities in a 2010–2012 observational study focused on influenza illness and vaccination in California and Oregon, USA. Methods Socio-demographic and health characteristics extracted from electronic medical records were compared among pregnant women who enrolled in the study, refused to participate, or were never reached for study invitation. These characteristics plus additional self-reported information were compared between women who enrolled in two study tracks: a prospective cohort vs. women enrolled following an acute respiratory illness (ARI) medical encounter. The characteristics of women who participated in weekly ARI surveillance (cohort enrollees, year one) and a 6-month follow-up interview (all enrollees) were also examined. Results In year one, we reached 51% (6938/13,655) of the potential participants we tried to contact by telephone, and 20% (1374/6938) of the women we invited agreed to join the prospective cohort. Women with chronic medical conditions, pregnancy complications, and medical encounters for ARI (prior to pregnancy or during the study period) were more likely to be reached for recruitment and more likely to enroll in the cohort. Twenty percent of cohort enrollees never started weekly surveillance reports; among those who did, reports were completed for 55% of the surveillance weeks. Receipt of the influenza vaccine was higher among women who joined the cohort (76%) than those who refused (56%) or were never reached (54%). In contrast, vaccine uptake among medical enrollees in year one (54%; 53/98) and two (52%; 79/151) was similar to other pregnant women in those years. Study site, white race, non-Hispanic ethnicity, and not having a child aged < 13 years at home were most consistently associated with joining as a cohort or medical enrollee and completing study activities after joining. Conclusions We observed systematic differences in socio-demographic and health characteristics across different levels of participant engagement and between cohort and medical enrollees. More methodological research and innovation in conducting prospective observational studies in this population are needed, especially when extended participant engagement and ongoing surveillance are required. |
| first_indexed | 2024-12-10T05:23:50Z |
| format | Article |
| id | doaj.art-f2946dc2766c452fa4b48a684ec5700a |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-10T05:23:50Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-f2946dc2766c452fa4b48a684ec5700a2022-12-22T02:00:45ZengBMCBMC Pregnancy and Childbirth1471-23932019-05-0119111410.1186/s12884-019-2280-0Factors associated with recruitment, surveillance participation, and retention in an observational study of pregnant women and influenzaMark G. Thompson0De-Kun Li1Allison L. Naleway2Jeannette R. Ferber3Michelle L. Henninger4Pat Shifflett5Leslie Z. Sokolow6Roxana Odouli7Tia L. Kauffman8Rebecca V. Fink9Joanna Bulkley10Janet D. Cragan11Sam Bozeman12Influenza Division, Centers for Disease Control and Prevention (CDC)Division of Research, Kaiser Foundation Research InstituteCenter for Health ResearchDivision of Research, Kaiser Foundation Research InstituteCenter for Health ResearchAbt Associates, Inc.Influenza Division, Centers for Disease Control and Prevention (CDC)Division of Research, Kaiser Foundation Research InstituteCenter for Health ResearchAbt Associates, Inc.Center for Health ResearchNational Center on Birth Defects and Developmental Disabilities, CDCAbt Associates, Inc.Abstract Background This report describes the results of recruitment efforts and the subsequent participation of pregnant women in study activities in a 2010–2012 observational study focused on influenza illness and vaccination in California and Oregon, USA. Methods Socio-demographic and health characteristics extracted from electronic medical records were compared among pregnant women who enrolled in the study, refused to participate, or were never reached for study invitation. These characteristics plus additional self-reported information were compared between women who enrolled in two study tracks: a prospective cohort vs. women enrolled following an acute respiratory illness (ARI) medical encounter. The characteristics of women who participated in weekly ARI surveillance (cohort enrollees, year one) and a 6-month follow-up interview (all enrollees) were also examined. Results In year one, we reached 51% (6938/13,655) of the potential participants we tried to contact by telephone, and 20% (1374/6938) of the women we invited agreed to join the prospective cohort. Women with chronic medical conditions, pregnancy complications, and medical encounters for ARI (prior to pregnancy or during the study period) were more likely to be reached for recruitment and more likely to enroll in the cohort. Twenty percent of cohort enrollees never started weekly surveillance reports; among those who did, reports were completed for 55% of the surveillance weeks. Receipt of the influenza vaccine was higher among women who joined the cohort (76%) than those who refused (56%) or were never reached (54%). In contrast, vaccine uptake among medical enrollees in year one (54%; 53/98) and two (52%; 79/151) was similar to other pregnant women in those years. Study site, white race, non-Hispanic ethnicity, and not having a child aged < 13 years at home were most consistently associated with joining as a cohort or medical enrollee and completing study activities after joining. Conclusions We observed systematic differences in socio-demographic and health characteristics across different levels of participant engagement and between cohort and medical enrollees. More methodological research and innovation in conducting prospective observational studies in this population are needed, especially when extended participant engagement and ongoing surveillance are required.http://link.springer.com/article/10.1186/s12884-019-2280-0CohortBiasPregnant womenInfluenzaInfluenza vaccine effectivenessAcute respiratory illness |
| spellingShingle | Mark G. Thompson De-Kun Li Allison L. Naleway Jeannette R. Ferber Michelle L. Henninger Pat Shifflett Leslie Z. Sokolow Roxana Odouli Tia L. Kauffman Rebecca V. Fink Joanna Bulkley Janet D. Cragan Sam Bozeman Factors associated with recruitment, surveillance participation, and retention in an observational study of pregnant women and influenza BMC Pregnancy and Childbirth Cohort Bias Pregnant women Influenza Influenza vaccine effectiveness Acute respiratory illness |
| title | Factors associated with recruitment, surveillance participation, and retention in an observational study of pregnant women and influenza |
| title_full | Factors associated with recruitment, surveillance participation, and retention in an observational study of pregnant women and influenza |
| title_fullStr | Factors associated with recruitment, surveillance participation, and retention in an observational study of pregnant women and influenza |
| title_full_unstemmed | Factors associated with recruitment, surveillance participation, and retention in an observational study of pregnant women and influenza |
| title_short | Factors associated with recruitment, surveillance participation, and retention in an observational study of pregnant women and influenza |
| title_sort | factors associated with recruitment surveillance participation and retention in an observational study of pregnant women and influenza |
| topic | Cohort Bias Pregnant women Influenza Influenza vaccine effectiveness Acute respiratory illness |
| url | http://link.springer.com/article/10.1186/s12884-019-2280-0 |
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