Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes
Long COVID-19 patients show systemic inflammation and persistent symptoms such as fatigue and malaise, profoundly affecting their quality of life. Since improving oxygenation can oppose inflammation at multiple tissue levels, we hypothesized that hyperbaric oxygen therapy (HBOT) could arrest inflamm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/10/1032 |
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| author | Simona Mrakic-Sposta Alessandra Vezzoli Giacomo Garetto Matteo Paganini Enrico Camporesi Tommaso Antonio Giacon Cinzia Dellanoce Jacopo Agrimi Gerardo Bosco |
| author_facet | Simona Mrakic-Sposta Alessandra Vezzoli Giacomo Garetto Matteo Paganini Enrico Camporesi Tommaso Antonio Giacon Cinzia Dellanoce Jacopo Agrimi Gerardo Bosco |
| author_sort | Simona Mrakic-Sposta |
| collection | DOAJ |
| description | Long COVID-19 patients show systemic inflammation and persistent symptoms such as fatigue and malaise, profoundly affecting their quality of life. Since improving oxygenation can oppose inflammation at multiple tissue levels, we hypothesized that hyperbaric oxygen therapy (HBOT) could arrest inflammation progression and thus relieve symptoms of COVID-19. We evaluated oxy-inflammation biomarkers in long COVID-19 subjects treated with HBOT and monitored with non-invasive methods. Five subjects (two athletes and three patients with other comorbidities) were assigned to receive HBOT: 100% inspired O<sub>2</sub> at 2.4 ATA in a multiplace hyperbaric chamber for 90 min (three athletes: 15 HBOT × 5 days/wk for 3 weeks; two patients affected by Idiopathic Sudden Sensorineural Hearing Loss: 30 HBOT × 5 days/wk for 6 weeks; and one patient with osteomyelitis: 30 HBOT × 5 days/wk for week for 6 weeks and, after a 30-day break, followed by a second cycle of 20 HBOT). Using saliva and/or urine samples, reactive oxygen species (ROS), antioxidant capacity, cytokines, lipids peroxidation, DNA damage, and renal status were assessed at T1_pre (basal level) and at T2_pre (basal level after treatment), and the results showed attenuated ROS production, lipid peroxidation, DNA damage, NO metabolites, and inflammation biomarker levels, especially in the athletes post-treatment. Thus, HBOT may represent an alternative non-invasive method for treating long COVID-19-induced long-lasting manifestations of oxy-inflammation. |
| first_indexed | 2024-03-10T21:04:21Z |
| format | Article |
| id | doaj.art-f294cd849c6c44098ac60d808778bcb6 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T21:04:21Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-f294cd849c6c44098ac60d808778bcb62023-11-19T17:19:28ZengMDPI AGMetabolites2218-19892023-09-011310103210.3390/metabo13101032Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary OutcomesSimona Mrakic-Sposta0Alessandra Vezzoli1Giacomo Garetto2Matteo Paganini3Enrico Camporesi4Tommaso Antonio Giacon5Cinzia Dellanoce6Jacopo Agrimi7Gerardo Bosco8Institute of Clinical Physiology, National Research Council (IFC-CNR), 20162 Milan, ItalyInstitute of Clinical Physiology, National Research Council (IFC-CNR), 20162 Milan, ItalyATIP Center for Hyperbaric Medicine, 35128 Padova, ItalyDepartment of Biomedical Sciences, University of Padova, 35122 Padova, ItalyDepartment of Biomedical Sciences, University of Padova, 35122 Padova, ItalyDepartment of Biomedical Sciences, University of Padova, 35122 Padova, ItalyInstitute of Clinical Physiology, National Research Council (IFC-CNR), 20162 Milan, ItalyDepartment of Biomedical Sciences, University of Padova, 35122 Padova, ItalyDepartment of Biomedical Sciences, University of Padova, 35122 Padova, ItalyLong COVID-19 patients show systemic inflammation and persistent symptoms such as fatigue and malaise, profoundly affecting their quality of life. Since improving oxygenation can oppose inflammation at multiple tissue levels, we hypothesized that hyperbaric oxygen therapy (HBOT) could arrest inflammation progression and thus relieve symptoms of COVID-19. We evaluated oxy-inflammation biomarkers in long COVID-19 subjects treated with HBOT and monitored with non-invasive methods. Five subjects (two athletes and three patients with other comorbidities) were assigned to receive HBOT: 100% inspired O<sub>2</sub> at 2.4 ATA in a multiplace hyperbaric chamber for 90 min (three athletes: 15 HBOT × 5 days/wk for 3 weeks; two patients affected by Idiopathic Sudden Sensorineural Hearing Loss: 30 HBOT × 5 days/wk for 6 weeks; and one patient with osteomyelitis: 30 HBOT × 5 days/wk for week for 6 weeks and, after a 30-day break, followed by a second cycle of 20 HBOT). Using saliva and/or urine samples, reactive oxygen species (ROS), antioxidant capacity, cytokines, lipids peroxidation, DNA damage, and renal status were assessed at T1_pre (basal level) and at T2_pre (basal level after treatment), and the results showed attenuated ROS production, lipid peroxidation, DNA damage, NO metabolites, and inflammation biomarker levels, especially in the athletes post-treatment. Thus, HBOT may represent an alternative non-invasive method for treating long COVID-19-induced long-lasting manifestations of oxy-inflammation.https://www.mdpi.com/2218-1989/13/10/1032long COVID-19HBOToxidative stressreactive oxygen speciesinflammationsaliva |
| spellingShingle | Simona Mrakic-Sposta Alessandra Vezzoli Giacomo Garetto Matteo Paganini Enrico Camporesi Tommaso Antonio Giacon Cinzia Dellanoce Jacopo Agrimi Gerardo Bosco Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes Metabolites long COVID-19 HBOT oxidative stress reactive oxygen species inflammation saliva |
| title | Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes |
| title_full | Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes |
| title_fullStr | Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes |
| title_full_unstemmed | Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes |
| title_short | Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes |
| title_sort | hyperbaric oxygen therapy counters oxidative stress inflammation driven symptoms in long covid 19 patients preliminary outcomes |
| topic | long COVID-19 HBOT oxidative stress reactive oxygen species inflammation saliva |
| url | https://www.mdpi.com/2218-1989/13/10/1032 |
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