The Segregated Intestinal Flow Model (SFM) for Drug Absorption and Drug Metabolism: Implications on Intestinal and Liver Metabolism and Drug–Drug Interactions
The properties of the segregated flow model (SFM), which considers split intestinal flow patterns perfusing an active enterocyte region that houses enzymes and transporters (<20% of the total intestinal blood flow) and an inactive serosal region (>80%), were compared to those of the traditiona...
Main Authors: | K. Sandy Pang, H. Benson Peng, Keumhan Noh |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-04-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/12/4/312 |
Similar Items
-
In-Depth Characterization of EpiIntestinal Microtissue as a Model for Intestinal Drug Absorption and Metabolism in Human
by: Yunhai Cui, et al.
Published: (2020-04-01) -
Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation
by: Arik Dahan, et al.
Published: (2021-02-01) -
Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
by: David Dahlgren, et al.
Published: (2019-08-01) -
Involvement of Transporters in Intestinal Drug–Drug Interactions of Oral Targeted Anticancer Drugs Assessed by Changes in Drug Absorption Time
by: David Malnoë, et al.
Published: (2022-11-01) -
Optimization of a Self-microemulsifying Drug Delivery System for Oral Administration of the Lipophilic Drug, Resveratrol: Enhanced Intestinal Permeability in Rat
by: Shahla Mirzaeei, et al.
Published: (2023-07-01)