Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing
Purpose With advancing endovascular technology and increasing interest in minimally invasive intra-arterial therapies such as stem cell and chemotherapy for cerebral disease, the establishment of a translational model with cerebral circulation accessible to microcatheters is needed. We report our ex...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Interventional Neuroradiology
2020-11-01
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| Series: | Neurointervention |
| Subjects: | |
| Online Access: | http://neurointervention.org/upload/pdf/neuroint-2020-00150.pdf |
| _version_ | 1797331867372879872 |
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| author | Kevin M. Camstra Visish M. Srinivasan Dalis Collins Stephen Chen Peter Kan Jeremiah Johnson |
| author_facet | Kevin M. Camstra Visish M. Srinivasan Dalis Collins Stephen Chen Peter Kan Jeremiah Johnson |
| author_sort | Kevin M. Camstra |
| collection | DOAJ |
| description | Purpose With advancing endovascular technology and increasing interest in minimally invasive intra-arterial therapies such as stem cell and chemotherapy for cerebral disease, the establishment of a translational model with cerebral circulation accessible to microcatheters is needed. We report our experience catheterizing canine cerebral circulation with microcatheters, present high-resolution angiographic images of the canine vascular anatomy, describe arterial branch flow patterns and provide measurements of canine arterial conduits. Materials and Methods Angiograms were performed on 10 intact purpose-bred hounds. Angiography, measurements of arterial conduits and catheterization information for intracranial arterial branches were obtained. Results Selective and superselective cerebral angiography was successful in all subjects. Relevant arterial mean diameters include the femoral (4.64 mm), aorta (9.38 mm), external carotid (3.65 mm), internal carotid arteries (1.6 mm), vertebrobasilar system and Circle of Willis branches. Catheterization of the Circle of Willis was achieved via the posterior circulation in all subjects tested (n=3) and the use of flow directed microcatheters resulted in reduced arterial tree deformation and improved superselection of intracranial vessels. Catheterization of the intracranial circulation was attempted but not achieved via the internal carotid artery (n=7) due to its tortuosity and subsequent catheter related vasospasm. Conclusion The canine cerebral vasculature is posterior circulation dominant. Anterior circulation angiography is achievable via the internal carotid artery, but direct cerebral arterial access is best achieved via the posterior circulation using flow-directed microcatheters. It is feasible to deliver intra-arterial therapies to selective vascular territories within the canine cerebral circulation, thus making it a viable animal model for testing novel intra-arterial cerebral treatments. |
| first_indexed | 2024-03-08T07:41:32Z |
| format | Article |
| id | doaj.art-f295e23db20f41408a62f5d83868f06f |
| institution | Directory Open Access Journal |
| issn | 2093-9043 2233-6273 |
| language | English |
| last_indexed | 2024-03-08T07:41:32Z |
| publishDate | 2020-11-01 |
| publisher | Korean Society of Interventional Neuroradiology |
| record_format | Article |
| series | Neurointervention |
| spelling | doaj.art-f295e23db20f41408a62f5d83868f06f2024-02-02T17:22:25ZengKorean Society of Interventional NeuroradiologyNeurointervention2093-90432233-62732020-11-0115310711610.5469/neuroint.2020.00150291Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy TestingKevin M. Camstra0Visish M. Srinivasan1Dalis Collins2Stephen Chen3Peter Kan4Jeremiah Johnson5 Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA Department of Surgery, Baylor College of Medicine, Houston, TX, USA Department of Radiology, Baylor College of Medicine, Houston, TX, USA Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USAPurpose With advancing endovascular technology and increasing interest in minimally invasive intra-arterial therapies such as stem cell and chemotherapy for cerebral disease, the establishment of a translational model with cerebral circulation accessible to microcatheters is needed. We report our experience catheterizing canine cerebral circulation with microcatheters, present high-resolution angiographic images of the canine vascular anatomy, describe arterial branch flow patterns and provide measurements of canine arterial conduits. Materials and Methods Angiograms were performed on 10 intact purpose-bred hounds. Angiography, measurements of arterial conduits and catheterization information for intracranial arterial branches were obtained. Results Selective and superselective cerebral angiography was successful in all subjects. Relevant arterial mean diameters include the femoral (4.64 mm), aorta (9.38 mm), external carotid (3.65 mm), internal carotid arteries (1.6 mm), vertebrobasilar system and Circle of Willis branches. Catheterization of the Circle of Willis was achieved via the posterior circulation in all subjects tested (n=3) and the use of flow directed microcatheters resulted in reduced arterial tree deformation and improved superselection of intracranial vessels. Catheterization of the intracranial circulation was attempted but not achieved via the internal carotid artery (n=7) due to its tortuosity and subsequent catheter related vasospasm. Conclusion The canine cerebral vasculature is posterior circulation dominant. Anterior circulation angiography is achievable via the internal carotid artery, but direct cerebral arterial access is best achieved via the posterior circulation using flow-directed microcatheters. It is feasible to deliver intra-arterial therapies to selective vascular territories within the canine cerebral circulation, thus making it a viable animal model for testing novel intra-arterial cerebral treatments.http://neurointervention.org/upload/pdf/neuroint-2020-00150.pdfangiographyanimal modelintraarterial deliveryneurovascular |
| spellingShingle | Kevin M. Camstra Visish M. Srinivasan Dalis Collins Stephen Chen Peter Kan Jeremiah Johnson Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing Neurointervention angiography animal model intraarterial delivery neurovascular |
| title | Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing |
| title_full | Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing |
| title_fullStr | Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing |
| title_full_unstemmed | Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing |
| title_short | Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing |
| title_sort | canine model for selective and superselective cerebral intra arterial therapy testing |
| topic | angiography animal model intraarterial delivery neurovascular |
| url | http://neurointervention.org/upload/pdf/neuroint-2020-00150.pdf |
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