Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration
Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple mechanical and chemical cues. Recently, we described that focal activation of the FGF pathway promotes the migration of the parapineal in the zebrafish epithalamus. How FGF ac...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-09-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/46275 |
| _version_ | 1811181519836807168 |
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| author | Lu Wei Amir Al Oustah Patrick Blader Myriam Roussigné |
| author_facet | Lu Wei Amir Al Oustah Patrick Blader Myriam Roussigné |
| author_sort | Lu Wei |
| collection | DOAJ |
| description | Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple mechanical and chemical cues. Recently, we described that focal activation of the FGF pathway promotes the migration of the parapineal in the zebrafish epithalamus. How FGF activity is restricted to leading cells in this system is, however, unclear. Here, we address the role of Notch signaling in modulating FGF activity within the parapineal. While Notch loss-of-function results in an increased number of parapineal cells activating the FGF pathway, global activation of Notch signaling decreases it; both contexts result in defects in parapineal migration and specification. Decreasing or increasing FGF signaling in a Notch loss-of-function context respectively rescues or aggravates parapineal migration defects without affecting parapineal cells specification. We propose that Notch signaling controls the migration of the parapineal through its capacity to restrict FGF pathway activation to a few leading cells. |
| first_indexed | 2024-04-11T09:18:46Z |
| format | Article |
| id | doaj.art-f2984a701c614690b817a4bd34d82bfa |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:18:46Z |
| publishDate | 2019-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-f2984a701c614690b817a4bd34d82bfa2022-12-22T04:32:15ZengeLife Sciences Publications LtdeLife2050-084X2019-09-01810.7554/eLife.46275Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migrationLu Wei0Amir Al Oustah1Patrick Blader2https://orcid.org/0000-0003-3299-6108Myriam Roussigné3https://orcid.org/0000-0002-4240-4105Centre de Biologie Intégrative (CBI), Centre de Biologie du Développement (CBD), Université de Toulouse, CNRS (UMR 5547), Toulouse, FranceCentre de Biologie Intégrative (CBI), Centre de Biologie du Développement (CBD), Université de Toulouse, CNRS (UMR 5547), Toulouse, FranceCentre de Biologie Intégrative (CBI), Centre de Biologie du Développement (CBD), Université de Toulouse, CNRS (UMR 5547), Toulouse, FranceCentre de Biologie Intégrative (CBI), Centre de Biologie du Développement (CBD), Université de Toulouse, CNRS (UMR 5547), Toulouse, FranceCoordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple mechanical and chemical cues. Recently, we described that focal activation of the FGF pathway promotes the migration of the parapineal in the zebrafish epithalamus. How FGF activity is restricted to leading cells in this system is, however, unclear. Here, we address the role of Notch signaling in modulating FGF activity within the parapineal. While Notch loss-of-function results in an increased number of parapineal cells activating the FGF pathway, global activation of Notch signaling decreases it; both contexts result in defects in parapineal migration and specification. Decreasing or increasing FGF signaling in a Notch loss-of-function context respectively rescues or aggravates parapineal migration defects without affecting parapineal cells specification. We propose that Notch signaling controls the migration of the parapineal through its capacity to restrict FGF pathway activation to a few leading cells.https://elifesciences.org/articles/46275collective cell migrationnotch signalingFGF pathwayleft right asymmetry |
| spellingShingle | Lu Wei Amir Al Oustah Patrick Blader Myriam Roussigné Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration eLife collective cell migration notch signaling FGF pathway left right asymmetry |
| title | Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration |
| title_full | Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration |
| title_fullStr | Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration |
| title_full_unstemmed | Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration |
| title_short | Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration |
| title_sort | notch signaling restricts fgf pathway activation in parapineal cells to promote their collective migration |
| topic | collective cell migration notch signaling FGF pathway left right asymmetry |
| url | https://elifesciences.org/articles/46275 |
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