Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance
Cytokines are proteins that act in the immune response and inflammation and have been associated with the development of some types of cancer, such as gastric cancer (GC). GC is a malignant neoplasm that ranks fifth in incidence and third in cancer-related mortality worldwide, making it a major publ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1347530/full |
| _version_ | 1797300324701044736 |
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| author | María Elena Reyes Victoria Pulgar Carolina Vivallo Carmen Gloria Ili Bárbara Mora-Lagos Priscilla Brebi |
| author_facet | María Elena Reyes Victoria Pulgar Carolina Vivallo Carmen Gloria Ili Bárbara Mora-Lagos Priscilla Brebi |
| author_sort | María Elena Reyes |
| collection | DOAJ |
| description | Cytokines are proteins that act in the immune response and inflammation and have been associated with the development of some types of cancer, such as gastric cancer (GC). GC is a malignant neoplasm that ranks fifth in incidence and third in cancer-related mortality worldwide, making it a major public health issue. Recent studies have focused on the role these cytokines may play in GC associated with angiogenesis, metastasis, and chemoresistance, which are key factors that can affect carcinogenesis and tumor progression, quality, and patient survival. These inflammatory mediators can be regulated by epigenetic modifications such as DNA methylation, histone protein modification, and non-coding RNA, which results in the silencing or overexpression of key genes in GC, presenting different targets of action, either direct or mediated by modifications in key genes of cytokine-related signaling pathways. This review seeks insight into the relationship between cytokine-associated epigenetic regulation and its potential effects on the different stages of development and chemoresistance in GC. |
| first_indexed | 2024-03-07T23:05:38Z |
| format | Article |
| id | doaj.art-f298b917b7164ef4a54ac11f0c812f25 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T23:05:38Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f298b917b7164ef4a54ac11f0c812f252024-02-22T05:06:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13475301347530Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistanceMaría Elena Reyes0Victoria Pulgar1Carolina Vivallo2Carmen Gloria Ili3Bárbara Mora-Lagos4Priscilla Brebi5Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Temuco, ChileMillennium Institute on Immunology and Immunotherapy. Laboratory of Integrative Biology, Center for Excellence in Translational Medicine-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco, ChileDepartamento de Anatomía Patológica, Universidad de La Frontera, Temuco, ChileMillennium Institute on Immunology and Immunotherapy. Laboratory of Integrative Biology, Center for Excellence in Translational Medicine-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco, ChileInstituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Temuco, ChileMillennium Institute on Immunology and Immunotherapy. Laboratory of Integrative Biology, Center for Excellence in Translational Medicine-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco, ChileCytokines are proteins that act in the immune response and inflammation and have been associated with the development of some types of cancer, such as gastric cancer (GC). GC is a malignant neoplasm that ranks fifth in incidence and third in cancer-related mortality worldwide, making it a major public health issue. Recent studies have focused on the role these cytokines may play in GC associated with angiogenesis, metastasis, and chemoresistance, which are key factors that can affect carcinogenesis and tumor progression, quality, and patient survival. These inflammatory mediators can be regulated by epigenetic modifications such as DNA methylation, histone protein modification, and non-coding RNA, which results in the silencing or overexpression of key genes in GC, presenting different targets of action, either direct or mediated by modifications in key genes of cytokine-related signaling pathways. This review seeks insight into the relationship between cytokine-associated epigenetic regulation and its potential effects on the different stages of development and chemoresistance in GC.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1347530/fullcytokinesepigenetic regulationgastric cancer (GC)chemoresistanceangiogenesismetastasis |
| spellingShingle | María Elena Reyes Victoria Pulgar Carolina Vivallo Carmen Gloria Ili Bárbara Mora-Lagos Priscilla Brebi Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance Frontiers in Immunology cytokines epigenetic regulation gastric cancer (GC) chemoresistance angiogenesis metastasis |
| title | Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance |
| title_full | Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance |
| title_fullStr | Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance |
| title_full_unstemmed | Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance |
| title_short | Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance |
| title_sort | epigenetic modulation of cytokine expression in gastric cancer influence on angiogenesis metastasis and chemoresistance |
| topic | cytokines epigenetic regulation gastric cancer (GC) chemoresistance angiogenesis metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1347530/full |
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