The regulatory role of m6A methylation modification in metabolic syndrome pathogenesis and progression
Metabolic syndromes are characterized by various complications caused by disrupted glucose and lipid metabolism, which are major factors affecting the health of a population. However, existing diagnostic and treatment strategies have limitations, such as the lack of early diagnostic and therapeutic...
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| Format: | Article |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1271874/full |
| _version_ | 1797257918181015552 |
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| author | Diwen Ye Diwen Ye Yongjiao Zhang Yongjiao Zhang Bingyang Zhang Junjun Liu Tianshu Wei Sumei Lu Sumei Lu |
| author_facet | Diwen Ye Diwen Ye Yongjiao Zhang Yongjiao Zhang Bingyang Zhang Junjun Liu Tianshu Wei Sumei Lu Sumei Lu |
| author_sort | Diwen Ye |
| collection | DOAJ |
| description | Metabolic syndromes are characterized by various complications caused by disrupted glucose and lipid metabolism, which are major factors affecting the health of a population. However, existing diagnostic and treatment strategies have limitations, such as the lack of early diagnostic and therapeutic approaches, variability in patient responses to treatment, and cost-effectiveness. Therefore, developing alternative solutions for metabolic syndromes is crucial. N6-methyladenosine (m6A) is one of the most abundant modifications that determine the fate of RNA. m6A modifications are closely associated with metabolic syndrome development and present novel prospects for clinical applications. Aberrant m6A modifications have been detected during inflammatory infiltration, apoptosis, autophagy, iron sagging, necrosis, and scorching during metabolic syndrome pathogenesis and progression. However, few reviews have systematically described the correlation between m6A modifications and these factors concerning metabolic syndrome pathogenesis and progression. This study summarizes the m6A methylation regulators and their roles in metabolic syndrome development, highlighting the potential of m6A modification as a biomarker in metabolic disorders. |
| first_indexed | 2024-04-24T22:45:16Z |
| format | Article |
| id | doaj.art-f29de2946dfd47e18eae24033555726b |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-24T22:45:16Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Physiology |
| spelling | doaj.art-f29de2946dfd47e18eae24033555726b2024-03-18T14:53:46ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-03-011510.3389/fphys.2024.12718741271874The regulatory role of m6A methylation modification in metabolic syndrome pathogenesis and progressionDiwen Ye0Diwen Ye1Yongjiao Zhang2Yongjiao Zhang3Bingyang Zhang4Junjun Liu5Tianshu Wei6Sumei Lu7Sumei Lu8Department of Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, ChinaSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, ChinaSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, ChinaSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, ChinaSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, ChinaSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, ChinaSchool of Medical Laboratory, Weifang Medical University, Weifang, Shandong, ChinaMetabolic syndromes are characterized by various complications caused by disrupted glucose and lipid metabolism, which are major factors affecting the health of a population. However, existing diagnostic and treatment strategies have limitations, such as the lack of early diagnostic and therapeutic approaches, variability in patient responses to treatment, and cost-effectiveness. Therefore, developing alternative solutions for metabolic syndromes is crucial. N6-methyladenosine (m6A) is one of the most abundant modifications that determine the fate of RNA. m6A modifications are closely associated with metabolic syndrome development and present novel prospects for clinical applications. Aberrant m6A modifications have been detected during inflammatory infiltration, apoptosis, autophagy, iron sagging, necrosis, and scorching during metabolic syndrome pathogenesis and progression. However, few reviews have systematically described the correlation between m6A modifications and these factors concerning metabolic syndrome pathogenesis and progression. This study summarizes the m6A methylation regulators and their roles in metabolic syndrome development, highlighting the potential of m6A modification as a biomarker in metabolic disorders.https://www.frontiersin.org/articles/10.3389/fphys.2024.1271874/fullm 6 Anonalcoholic fatty liver diseasediabetesatherosclerosisinflammatory responseautophagy |
| spellingShingle | Diwen Ye Diwen Ye Yongjiao Zhang Yongjiao Zhang Bingyang Zhang Junjun Liu Tianshu Wei Sumei Lu Sumei Lu The regulatory role of m6A methylation modification in metabolic syndrome pathogenesis and progression Frontiers in Physiology m 6 A nonalcoholic fatty liver disease diabetes atherosclerosis inflammatory response autophagy |
| title | The regulatory role of m6A methylation modification in metabolic syndrome pathogenesis and progression |
| title_full | The regulatory role of m6A methylation modification in metabolic syndrome pathogenesis and progression |
| title_fullStr | The regulatory role of m6A methylation modification in metabolic syndrome pathogenesis and progression |
| title_full_unstemmed | The regulatory role of m6A methylation modification in metabolic syndrome pathogenesis and progression |
| title_short | The regulatory role of m6A methylation modification in metabolic syndrome pathogenesis and progression |
| title_sort | regulatory role of m6a methylation modification in metabolic syndrome pathogenesis and progression |
| topic | m 6 A nonalcoholic fatty liver disease diabetes atherosclerosis inflammatory response autophagy |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1271874/full |
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