Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in Macrophages to Enhance Intracellular Survival

Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in Macrophages to Enhance Intracellular Survival

Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that exploits moonlighting functions of its proteins to interfere with host cell functions. PE/PPE proteins utilize host inflammatory signaling and cell death pathways to promote pathogenesis. We report that M. tb PE6 protein (Rv0335c)...

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Bibliographic Details
Main Authors: Neha Sharma, Mohd Shariq, Neha Quadir, Jasdeep Singh, Javaid A. Sheikh, Seyed E. Hasnain, Nasreen Z. Ehtesham
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
autophagy
apoptosis
proinflammatory cytokines
TLR4
iron acquisition
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.696491/full

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