Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas
Background: Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. Method: Various bioinf...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
|
| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S193652332030468X |
| _version_ | 1818917382880493568 |
|---|---|
| author | Haosheng Ni Hui Sun Miaosen Zheng Tingting Bian Jian Liu Xiaoli Li Jianguo Zhang Yifei Liu |
| author_facet | Haosheng Ni Hui Sun Miaosen Zheng Tingting Bian Jian Liu Xiaoli Li Jianguo Zhang Yifei Liu |
| author_sort | Haosheng Ni |
| collection | DOAJ |
| description | Background: Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. Method: Various bioinformatics tools were used to explore the role of the STAT family in HNSC. Result: The mRNA levels of STAT1/2/4/5A/6 were significantly upregulated in HNSC tissues. The levels of STAT1/2/4/5A/6 could be used for the detection of HNSC. HNSC patients with a high level of STAT5A had a poor overall survival and relapse-free survival. A moderate to high correlation was obtained between the STAT family and HNSC. Genetic alteration revealed that STAT1/2/3/4/5A/5B/6 were altered in 6%, 5%, 7%, 8%, 6%, 6%, and 4% of the queried TCGA HNSC samples, respectively. Immune infiltrations analysis suggested a significant association between STAT5A expression and abundance of specific immune cells. Further, copy number alteration of STAT5A could certainly inhibit infiltration level. Moreover, a close correlation was obtained between STAT5A level and the expression of immune markers in HNSC. Several kinase targets and transcription factor targets of STAT5A in HNSC were also identified. Enrichment analysis suggested that STAT5A and co-expression genes were mainly responsible for adaptive immune response, T cell activation, cytokine-cytokine receptor interaction, chemokine signaling pathway, cell-adhesion molecules, and ribosome and RNA transport. Conclusion: Our results provided additional data for the expression and clinical significance of the STAT family in HNSC, and further study should be performed to verify these. |
| first_indexed | 2024-12-20T00:33:11Z |
| format | Article |
| id | doaj.art-f2a0621478874dfdb5c11137ac5a9833 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-20T00:33:11Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-f2a0621478874dfdb5c11137ac5a98332022-12-21T19:59:53ZengElsevierTranslational Oncology1936-52332021-01-01141100976Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomasHaosheng Ni0Hui Sun1Miaosen Zheng2Tingting Bian3Jian Liu4Xiaoli Li5Jianguo Zhang6Yifei Liu7Department of Otolaryngology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, PR ChinaDepartment of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, PR ChinaDepartment of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, PR ChinaDepartment of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, PR ChinaDepartment of Chemotherapy, Affiliated Hospital of Nantong University, Nantong, Jiangsu, PR ChinaDepartment of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, PR ChinaDepartment of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, PR China; Corresponding authors.Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, PR China; Corresponding authors.Background: Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. Method: Various bioinformatics tools were used to explore the role of the STAT family in HNSC. Result: The mRNA levels of STAT1/2/4/5A/6 were significantly upregulated in HNSC tissues. The levels of STAT1/2/4/5A/6 could be used for the detection of HNSC. HNSC patients with a high level of STAT5A had a poor overall survival and relapse-free survival. A moderate to high correlation was obtained between the STAT family and HNSC. Genetic alteration revealed that STAT1/2/3/4/5A/5B/6 were altered in 6%, 5%, 7%, 8%, 6%, 6%, and 4% of the queried TCGA HNSC samples, respectively. Immune infiltrations analysis suggested a significant association between STAT5A expression and abundance of specific immune cells. Further, copy number alteration of STAT5A could certainly inhibit infiltration level. Moreover, a close correlation was obtained between STAT5A level and the expression of immune markers in HNSC. Several kinase targets and transcription factor targets of STAT5A in HNSC were also identified. Enrichment analysis suggested that STAT5A and co-expression genes were mainly responsible for adaptive immune response, T cell activation, cytokine-cytokine receptor interaction, chemokine signaling pathway, cell-adhesion molecules, and ribosome and RNA transport. Conclusion: Our results provided additional data for the expression and clinical significance of the STAT family in HNSC, and further study should be performed to verify these.http://www.sciencedirect.com/science/article/pii/S193652332030468XHead and neck squamous cell carcinomasSTAT familyBiomarkerBioinformatics analysis |
| spellingShingle | Haosheng Ni Hui Sun Miaosen Zheng Tingting Bian Jian Liu Xiaoli Li Jianguo Zhang Yifei Liu Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas Translational Oncology Head and neck squamous cell carcinomas STAT family Biomarker Bioinformatics analysis |
| title | Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas |
| title_full | Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas |
| title_fullStr | Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas |
| title_full_unstemmed | Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas |
| title_short | Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas |
| title_sort | mining database for the expression and clinical significance of stat family in head and neck squamous cell carcinomas |
| topic | Head and neck squamous cell carcinomas STAT family Biomarker Bioinformatics analysis |
| url | http://www.sciencedirect.com/science/article/pii/S193652332030468X |
| work_keys_str_mv | AT haoshengni miningdatabasefortheexpressionandclinicalsignificanceofstatfamilyinheadandnecksquamouscellcarcinomas AT huisun miningdatabasefortheexpressionandclinicalsignificanceofstatfamilyinheadandnecksquamouscellcarcinomas AT miaosenzheng miningdatabasefortheexpressionandclinicalsignificanceofstatfamilyinheadandnecksquamouscellcarcinomas AT tingtingbian miningdatabasefortheexpressionandclinicalsignificanceofstatfamilyinheadandnecksquamouscellcarcinomas AT jianliu miningdatabasefortheexpressionandclinicalsignificanceofstatfamilyinheadandnecksquamouscellcarcinomas AT xiaolili miningdatabasefortheexpressionandclinicalsignificanceofstatfamilyinheadandnecksquamouscellcarcinomas AT jianguozhang miningdatabasefortheexpressionandclinicalsignificanceofstatfamilyinheadandnecksquamouscellcarcinomas AT yifeiliu miningdatabasefortheexpressionandclinicalsignificanceofstatfamilyinheadandnecksquamouscellcarcinomas |