Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza?
Influenza A virus (IAV) represents an ongoing threat to human and animal health worldwide. The generation of IAV-resistant chickens through genetic modification and/or selective breeding may help prevent viral spread. The feasibility of creating genetically modified birds has already been demonstrat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/10/10/561 |
| _version_ | 1819012746297999360 |
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| author | Fong Yang Looi Michelle L. Baker Thomas Townson Mathilde Richard Ben Novak Tim J. Doran Kirsty R. Short |
| author_facet | Fong Yang Looi Michelle L. Baker Thomas Townson Mathilde Richard Ben Novak Tim J. Doran Kirsty R. Short |
| author_sort | Fong Yang Looi |
| collection | DOAJ |
| description | Influenza A virus (IAV) represents an ongoing threat to human and animal health worldwide. The generation of IAV-resistant chickens through genetic modification and/or selective breeding may help prevent viral spread. The feasibility of creating genetically modified birds has already been demonstrated with the insertion of transgenes that target IAV into the genomes of chickens. This approach has been met with some success in minimising the spread of IAV but has limitations in terms of its ability to prevent the emergence of disease. An alternate approach is the use of genetic engineering to improve host resistance by targeting the antiviral immune responses of poultry to IAV. Harnessing such resistance mechanisms in a “genetic restoration” approach may hold the greatest promise yet for generating disease resistant chickens. Continuing to identify genes associated with natural resistance in poultry provides the opportunity to identify new targets for genetic modification and/or selective breeding. However, as with any new technology, economic, societal, and legislative barriers will need to be overcome before we are likely to see commercialisation of genetically modified birds. |
| first_indexed | 2024-12-21T01:48:57Z |
| format | Article |
| id | doaj.art-f2a17961453c4932b7c0f4d7b2962a31 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-21T01:48:57Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f2a17961453c4932b7c0f4d7b2962a312022-12-21T19:19:56ZengMDPI AGViruses1999-49152018-10-01101056110.3390/v10100561v10100561Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza?Fong Yang Looi0Michelle L. Baker1Thomas Townson2Mathilde Richard3Ben Novak4Tim J. Doran5Kirsty R. Short6School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, AustraliaCSIRO, Australian Animal Health Laboratory, Health and Biosecurity Business Unit, Geelong, VIC 3219, AustraliaSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, AustraliaDepartment of Viroscience, Erasmus Medical Centre, 3015 GD Rotterdam, The NetherlandsCSIRO, Australian Animal Health Laboratory, Health and Biosecurity Business Unit, Geelong, VIC 3219, AustraliaCSIRO, Australian Animal Health Laboratory, Health and Biosecurity Business Unit, Geelong, VIC 3219, AustraliaSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, AustraliaInfluenza A virus (IAV) represents an ongoing threat to human and animal health worldwide. The generation of IAV-resistant chickens through genetic modification and/or selective breeding may help prevent viral spread. The feasibility of creating genetically modified birds has already been demonstrated with the insertion of transgenes that target IAV into the genomes of chickens. This approach has been met with some success in minimising the spread of IAV but has limitations in terms of its ability to prevent the emergence of disease. An alternate approach is the use of genetic engineering to improve host resistance by targeting the antiviral immune responses of poultry to IAV. Harnessing such resistance mechanisms in a “genetic restoration” approach may hold the greatest promise yet for generating disease resistant chickens. Continuing to identify genes associated with natural resistance in poultry provides the opportunity to identify new targets for genetic modification and/or selective breeding. However, as with any new technology, economic, societal, and legislative barriers will need to be overcome before we are likely to see commercialisation of genetically modified birds.http://www.mdpi.com/1999-4915/10/10/561avian influenzachickenstransgenicsGMOpoultry |
| spellingShingle | Fong Yang Looi Michelle L. Baker Thomas Townson Mathilde Richard Ben Novak Tim J. Doran Kirsty R. Short Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza? Viruses avian influenza chickens transgenics GMO poultry |
| title | Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza? |
| title_full | Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza? |
| title_fullStr | Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza? |
| title_full_unstemmed | Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza? |
| title_short | Creating Disease Resistant Chickens: A Viable Solution to Avian Influenza? |
| title_sort | creating disease resistant chickens a viable solution to avian influenza |
| topic | avian influenza chickens transgenics GMO poultry |
| url | http://www.mdpi.com/1999-4915/10/10/561 |
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