Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials
The world-wide increasing incidence of liver injury has attracted scientific interest in the exploration of better treatment or adjuvant treatment therapies. This study investigated the effects of methanol extract of Zingiber officinale (Roscoe) rhizome (MEZOR) in a Wistar rat model of carbon tetrac...
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| Format: | Article |
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Elsevier
2019-01-01
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| Series: | Toxicology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750018304311 |
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| author | Gracious Oluwamayowa Oke Adegboyega Adeleke Abiodun Christian Eseigbe Imafidon Barinem Fortune Monsi |
| author_facet | Gracious Oluwamayowa Oke Adegboyega Adeleke Abiodun Christian Eseigbe Imafidon Barinem Fortune Monsi |
| author_sort | Gracious Oluwamayowa Oke |
| collection | DOAJ |
| description | The world-wide increasing incidence of liver injury has attracted scientific interest in the exploration of better treatment or adjuvant treatment therapies. This study investigated the effects of methanol extract of Zingiber officinale (Roscoe) rhizome (MEZOR) in a Wistar rat model of carbon tetrachloride (CCl4)-induced liver injury. The study recruited thirty female Wistar rats that received graded doses of MEZOR (determined by its LD50) by oral gavage through an oral canula, for 4 consecutive weeks following 1 week oral administration of CCl4 (0.7 ml/kg in olive oil; 1:1, v/v) while livolin forte® (5.2 mg/kg p.o.) was used as a standard. CCl4 induced deleterious hepatic effects as revealed by the liver function biomarkers (AST, ALT, ALP and total protein), antioxidant indicators (GSH and CAT) and histopathological effects, demonstrated by H & E, Gordon and Sweet, Masson’s trichrome, PAS staining techniques as well as by quantificational analyses of the liver micrographs, using image–J. MEZOR treatment was associated with a dose-dependent and significant mitigation of the aforementioned parameters (p < 0.05). This study concluded that MEZOR is a potential therapeutic choice in the adjuvant treatment of subjects with chemically-induced liver injury. Keywords: CCl4, Zingiber officinale, Liver injury, Histopathology, Female Wistar rats |
| first_indexed | 2024-12-20T04:01:41Z |
| format | Article |
| id | doaj.art-f2a21c2fb0a84c6d89d51b27b2e94fd6 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-20T04:01:41Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-f2a21c2fb0a84c6d89d51b27b2e94fd62022-12-21T19:54:09ZengElsevierToxicology Reports2214-75002019-01-016416425Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentialsGracious Oluwamayowa Oke0Adegboyega Adeleke Abiodun1Christian Eseigbe Imafidon2Barinem Fortune Monsi3Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria; Corresponding author.Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, NigeriaDepartment of Physiology, Faculty of Basic Medical and Health Sciences, Bowen University, Iwo, Osun State, Nigeria; Department of Physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, NigeriaDepartment of Physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, NigeriaThe world-wide increasing incidence of liver injury has attracted scientific interest in the exploration of better treatment or adjuvant treatment therapies. This study investigated the effects of methanol extract of Zingiber officinale (Roscoe) rhizome (MEZOR) in a Wistar rat model of carbon tetrachloride (CCl4)-induced liver injury. The study recruited thirty female Wistar rats that received graded doses of MEZOR (determined by its LD50) by oral gavage through an oral canula, for 4 consecutive weeks following 1 week oral administration of CCl4 (0.7 ml/kg in olive oil; 1:1, v/v) while livolin forte® (5.2 mg/kg p.o.) was used as a standard. CCl4 induced deleterious hepatic effects as revealed by the liver function biomarkers (AST, ALT, ALP and total protein), antioxidant indicators (GSH and CAT) and histopathological effects, demonstrated by H & E, Gordon and Sweet, Masson’s trichrome, PAS staining techniques as well as by quantificational analyses of the liver micrographs, using image–J. MEZOR treatment was associated with a dose-dependent and significant mitigation of the aforementioned parameters (p < 0.05). This study concluded that MEZOR is a potential therapeutic choice in the adjuvant treatment of subjects with chemically-induced liver injury. Keywords: CCl4, Zingiber officinale, Liver injury, Histopathology, Female Wistar ratshttp://www.sciencedirect.com/science/article/pii/S2214750018304311 |
| spellingShingle | Gracious Oluwamayowa Oke Adegboyega Adeleke Abiodun Christian Eseigbe Imafidon Barinem Fortune Monsi Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials Toxicology Reports |
| title | Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials |
| title_full | Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials |
| title_fullStr | Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials |
| title_full_unstemmed | Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials |
| title_short | Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials |
| title_sort | zingiber officinale roscoe mitigates ccl4 induced liver histopathology and biochemical derangements through antioxidant membrane stabilizing and tissue regenerating potentials |
| url | http://www.sciencedirect.com/science/article/pii/S2214750018304311 |
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