Formulation of Tioconazole and <i>Melaleuca alternifolia</i> Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment
Onychomycosis is a disease that affects many adults, whose treatment includes both oral and topical therapies with low cure rates. The topical therapy is less effective but causes fewer side effects. This is why the development of an effective, easy to apply formulation for topical treatment is of h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/23/5544 |
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| author | Barbara Vörös-Horváth Sourav Das Ala’ Salem Sándor Nagy Andrea Böszörményi Tamás Kőszegi Szilárd Pál Aleksandar Széchenyi |
| author_facet | Barbara Vörös-Horváth Sourav Das Ala’ Salem Sándor Nagy Andrea Böszörményi Tamás Kőszegi Szilárd Pál Aleksandar Széchenyi |
| author_sort | Barbara Vörös-Horváth |
| collection | DOAJ |
| description | Onychomycosis is a disease that affects many adults, whose treatment includes both oral and topical therapies with low cure rates. The topical therapy is less effective but causes fewer side effects. This is why the development of an effective, easy to apply formulation for topical treatment is of high importance. We have used a nanotechnological approach to formulate Pickering emulsions (PEs) with well-defined properties to achieve site-specific delivery for antifungal drug combination of tioconazole and <i>Melaleuca alternifolia</i> essential oil. Silica nanoparticles with tailored size and partially hydrophobic surface have been synthesized and used for the stabilization of PEs. In vitro diffusion studies have been performed to evaluate the drug delivery properties of PEs. Ethanolic solution (ES) and conventional emulsions (CE) have been used as reference drug formulations. The examination of the antifungal effect of PEs has been performed on <i>Candida albicans</i> and <i>Trichophyton rubrum</i> as main pathogens. In vitro microbiological experimental results suggest that PEs are better candidates for onychomycosis topical treatment than CE or ES of the examined drugs. The used drugs have shown a significant synergistic effect, and the combination with an effective drug delivery system can result in a promising drug form for the topical treatment of onychomycosis. |
| first_indexed | 2024-03-10T14:33:32Z |
| format | Article |
| id | doaj.art-f2a335b10c8b459398195305669dcf1b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:33:32Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f2a335b10c8b459398195305669dcf1b2023-11-20T22:25:56ZengMDPI AGMolecules1420-30492020-11-012523554410.3390/molecules25235544Formulation of Tioconazole and <i>Melaleuca alternifolia</i> Essential Oil Pickering Emulsions for Onychomycosis Topical TreatmentBarbara Vörös-Horváth0Sourav Das1Ala’ Salem2Sándor Nagy3Andrea Böszörményi4Tamás Kőszegi5Szilárd Pál6Aleksandar Széchenyi7Institute of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, HungaryDepartment of Laboratory Medicine, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, HungaryInstitute of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, HungaryDepartment of Pharmacognosy, Faculty of Pharmacy, Semmelweis University, H-1085 Budapest, HungaryDepartment of Laboratory Medicine, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, HungaryInstitute of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, HungaryOnychomycosis is a disease that affects many adults, whose treatment includes both oral and topical therapies with low cure rates. The topical therapy is less effective but causes fewer side effects. This is why the development of an effective, easy to apply formulation for topical treatment is of high importance. We have used a nanotechnological approach to formulate Pickering emulsions (PEs) with well-defined properties to achieve site-specific delivery for antifungal drug combination of tioconazole and <i>Melaleuca alternifolia</i> essential oil. Silica nanoparticles with tailored size and partially hydrophobic surface have been synthesized and used for the stabilization of PEs. In vitro diffusion studies have been performed to evaluate the drug delivery properties of PEs. Ethanolic solution (ES) and conventional emulsions (CE) have been used as reference drug formulations. The examination of the antifungal effect of PEs has been performed on <i>Candida albicans</i> and <i>Trichophyton rubrum</i> as main pathogens. In vitro microbiological experimental results suggest that PEs are better candidates for onychomycosis topical treatment than CE or ES of the examined drugs. The used drugs have shown a significant synergistic effect, and the combination with an effective drug delivery system can result in a promising drug form for the topical treatment of onychomycosis.https://www.mdpi.com/1420-3049/25/23/5544pickering emulsionsonychomycosis topical treatmenttioconazoletea tree essential oilantifungal activity |
| spellingShingle | Barbara Vörös-Horváth Sourav Das Ala’ Salem Sándor Nagy Andrea Böszörményi Tamás Kőszegi Szilárd Pál Aleksandar Széchenyi Formulation of Tioconazole and <i>Melaleuca alternifolia</i> Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment Molecules pickering emulsions onychomycosis topical treatment tioconazole tea tree essential oil antifungal activity |
| title | Formulation of Tioconazole and <i>Melaleuca alternifolia</i> Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment |
| title_full | Formulation of Tioconazole and <i>Melaleuca alternifolia</i> Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment |
| title_fullStr | Formulation of Tioconazole and <i>Melaleuca alternifolia</i> Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment |
| title_full_unstemmed | Formulation of Tioconazole and <i>Melaleuca alternifolia</i> Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment |
| title_short | Formulation of Tioconazole and <i>Melaleuca alternifolia</i> Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment |
| title_sort | formulation of tioconazole and i melaleuca alternifolia i essential oil pickering emulsions for onychomycosis topical treatment |
| topic | pickering emulsions onychomycosis topical treatment tioconazole tea tree essential oil antifungal activity |
| url | https://www.mdpi.com/1420-3049/25/23/5544 |
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