Ameliorative effects of hispidulin on high glucose-mediated endothelial dysfunction via inhibition of PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling in endothelial cells

Ameliorative effects of hispidulin on high glucose-mediated endothelial dysfunction via inhibition of PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling in endothelial cells

Endothelial dysfunction is closely relevant to atherosclerosis complications in diabetic patients. Hispidulin, a flavone derived from the herb Salvia plebeia R. Br., has numerous biological properties including anti-inflammatory and antioxidative effects, but the underlying mechanism of its anti-inf...

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Bibliographic Details
Main Authors: Weiwei Qin, Junxiao Xi, Baiqiu He, Baobao Zhang, Huiling Luan, Feihua Wu
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Journal of Functional Foods
Subjects:
Hispidulin
Endothelial dysfunction
PKCβII
NLRP3 inflammasome
Oxidative stress
High glucose
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616302997

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