Posterior Pole Asymmetry Analysis as a Diagnostic Tool in Glaucoma Suspects: An Electrophysiological Approach
Andrew Tirsi,1,2,* Paras P Shah,1,* Vasiliki Gliagias,1 Daniel Barmas-Alamdari,2 Derek Orshan,2 Joby Tsai,2 Celso Tello1,2 1Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, 11549, USA; 2Department of Ophthalmology, Manhattan Eye, Ear, and Throat Hospi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-06-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/posterior-pole-asymmetry-analysis-as-a-diagnostic-tool-in-glaucoma-sus-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1797789395036667904 |
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| author | Tirsi A Shah PP Gliagias V Barmas-Alamdari D Orshan D Tsai J Tello C |
| author_facet | Tirsi A Shah PP Gliagias V Barmas-Alamdari D Orshan D Tsai J Tello C |
| author_sort | Tirsi A |
| collection | DOAJ |
| description | Andrew Tirsi,1,2,* Paras P Shah,1,* Vasiliki Gliagias,1 Daniel Barmas-Alamdari,2 Derek Orshan,2 Joby Tsai,2 Celso Tello1,2 1Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, 11549, USA; 2Department of Ophthalmology, Manhattan Eye, Ear, and Throat Hospital, New York City, NY, 10065, USA*These authors contributed equally to this workCorrespondence: Andrew Tirsi, 210 East 64th Street, New York City, NY, 10065, USA, Tel +1 201 982 4168, Email ATirsi@northwell.eduPurpose: Spectral domain optical coherence tomography (SD-OCT) with posterior pole asymmetry analysis (PPAA) provides a mapping of posterior pole retinal thickness with asymmetry analysis between hemispheres of each eye. We investigated whether these structural abnormalities were correlated with functional retinal ganglion cell (RGC) loss, quantified by steady state pattern electroretinogram (ssPERG), in glaucoma suspects (GS).Methods: Twenty GS (34 eyes) were enrolled in a prospective study at the Manhattan Eye, Ear, and Throat Hospital. All subjects underwent ophthalmological examination, including Humphrey visual field, Spectralis Glaucoma Module Premium Edition (GMPE) SD-OCT PPAA, and ssPERG testing. The ability of ssPERG parameters (Magnitude [Mag, μv], MagnitudeD [MagD, μv], and MagD/Mag ratio) to predict PPAA thickness (total, superior, and inferior thickness, [μm]) was tested via adjusted multivariate linear regression analysis.Results: Mag explained 8% of variance in total PPAA change (F(1,29)=6.33, B=6.86, 95% CI: 1.29– 12.44, p=0.018), 8% in superior PPAA change (F(1,29)=5.57, B=6.92, 95% CI: 0.92– 12.92, p=0.025), and 7.1% in inferior PPAA change (F(1,29)=5.83, B=6.80, 95% CI: 1.04– 12.56, p=0.022). Similarly, MagD explained 9.7% of variance in total PPAA change (F(1,29)=8.09, B=6.47, 95% CI: 1.82– 11.13, p=0.008), 10% in superior PPAA change (F(1,29)=7.33, B=6.63, 95% CI: 1.62– 11.63, p=0.011), and 8.5% in inferior PPAA change (F(1,29)=7.25, B=6.36, 95% CI: 1.53– 11.18, p=0.012). MagD/Mag ratio and PPAA were not significantly associated.Conclusion: To the best of our knowledge, this is the first study demonstrating a positive relationship between RGC dysfunction and retinal thickness changes between the superior and inferior hemispheres. The detection of asymmetrical structural loss, combined with functional RGC assessment using ssPERG, may be an informative tool for early glaucoma diagnosis.Keywords: PPAA, PERG, glaucoma, posterior pole, asymmetry |
| first_indexed | 2024-03-13T01:50:02Z |
| format | Article |
| id | doaj.art-f2a4fb1e25974106bf73865152fcc931 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-03-13T01:50:02Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-f2a4fb1e25974106bf73865152fcc9312023-07-02T19:49:18ZengDove Medical PressClinical Ophthalmology1177-54832023-06-01Volume 171777178784614Posterior Pole Asymmetry Analysis as a Diagnostic Tool in Glaucoma Suspects: An Electrophysiological ApproachTirsi AShah PPGliagias VBarmas-Alamdari DOrshan DTsai JTello CAndrew Tirsi,1,2,* Paras P Shah,1,* Vasiliki Gliagias,1 Daniel Barmas-Alamdari,2 Derek Orshan,2 Joby Tsai,2 Celso Tello1,2 1Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, 11549, USA; 2Department of Ophthalmology, Manhattan Eye, Ear, and Throat Hospital, New York City, NY, 10065, USA*These authors contributed equally to this workCorrespondence: Andrew Tirsi, 210 East 64th Street, New York City, NY, 10065, USA, Tel +1 201 982 4168, Email ATirsi@northwell.eduPurpose: Spectral domain optical coherence tomography (SD-OCT) with posterior pole asymmetry analysis (PPAA) provides a mapping of posterior pole retinal thickness with asymmetry analysis between hemispheres of each eye. We investigated whether these structural abnormalities were correlated with functional retinal ganglion cell (RGC) loss, quantified by steady state pattern electroretinogram (ssPERG), in glaucoma suspects (GS).Methods: Twenty GS (34 eyes) were enrolled in a prospective study at the Manhattan Eye, Ear, and Throat Hospital. All subjects underwent ophthalmological examination, including Humphrey visual field, Spectralis Glaucoma Module Premium Edition (GMPE) SD-OCT PPAA, and ssPERG testing. The ability of ssPERG parameters (Magnitude [Mag, μv], MagnitudeD [MagD, μv], and MagD/Mag ratio) to predict PPAA thickness (total, superior, and inferior thickness, [μm]) was tested via adjusted multivariate linear regression analysis.Results: Mag explained 8% of variance in total PPAA change (F(1,29)=6.33, B=6.86, 95% CI: 1.29– 12.44, p=0.018), 8% in superior PPAA change (F(1,29)=5.57, B=6.92, 95% CI: 0.92– 12.92, p=0.025), and 7.1% in inferior PPAA change (F(1,29)=5.83, B=6.80, 95% CI: 1.04– 12.56, p=0.022). Similarly, MagD explained 9.7% of variance in total PPAA change (F(1,29)=8.09, B=6.47, 95% CI: 1.82– 11.13, p=0.008), 10% in superior PPAA change (F(1,29)=7.33, B=6.63, 95% CI: 1.62– 11.63, p=0.011), and 8.5% in inferior PPAA change (F(1,29)=7.25, B=6.36, 95% CI: 1.53– 11.18, p=0.012). MagD/Mag ratio and PPAA were not significantly associated.Conclusion: To the best of our knowledge, this is the first study demonstrating a positive relationship between RGC dysfunction and retinal thickness changes between the superior and inferior hemispheres. The detection of asymmetrical structural loss, combined with functional RGC assessment using ssPERG, may be an informative tool for early glaucoma diagnosis.Keywords: PPAA, PERG, glaucoma, posterior pole, asymmetryhttps://www.dovepress.com/posterior-pole-asymmetry-analysis-as-a-diagnostic-tool-in-glaucoma-sus-peer-reviewed-fulltext-article-OPTHppaapergglaucomaposterior poleasymmetry |
| spellingShingle | Tirsi A Shah PP Gliagias V Barmas-Alamdari D Orshan D Tsai J Tello C Posterior Pole Asymmetry Analysis as a Diagnostic Tool in Glaucoma Suspects: An Electrophysiological Approach Clinical Ophthalmology ppaa perg glaucoma posterior pole asymmetry |
| title | Posterior Pole Asymmetry Analysis as a Diagnostic Tool in Glaucoma Suspects: An Electrophysiological Approach |
| title_full | Posterior Pole Asymmetry Analysis as a Diagnostic Tool in Glaucoma Suspects: An Electrophysiological Approach |
| title_fullStr | Posterior Pole Asymmetry Analysis as a Diagnostic Tool in Glaucoma Suspects: An Electrophysiological Approach |
| title_full_unstemmed | Posterior Pole Asymmetry Analysis as a Diagnostic Tool in Glaucoma Suspects: An Electrophysiological Approach |
| title_short | Posterior Pole Asymmetry Analysis as a Diagnostic Tool in Glaucoma Suspects: An Electrophysiological Approach |
| title_sort | posterior pole asymmetry analysis as a diagnostic tool in glaucoma suspects an electrophysiological approach |
| topic | ppaa perg glaucoma posterior pole asymmetry |
| url | https://www.dovepress.com/posterior-pole-asymmetry-analysis-as-a-diagnostic-tool-in-glaucoma-sus-peer-reviewed-fulltext-article-OPTH |
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