Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation
ABSTRACT Aims: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance. Material and Methods: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group...
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| Language: | English |
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Sociedade Brasileira de Urologia
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| Series: | International Brazilian Journal of Urology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000601092&lng=en&tlng=en |
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| author | Sher Singh Yadav Rohit Bhattar Lokesh Sharma Gautam Banga Trilok Chandra Sadasukhi |
| author_facet | Sher Singh Yadav Rohit Bhattar Lokesh Sharma Gautam Banga Trilok Chandra Sadasukhi |
| author_sort | Sher Singh Yadav |
| collection | DOAJ |
| description | ABSTRACT Aims: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance. Material and Methods: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group (group-1) consisted of age matched normal male patients, who underwent surveillance or diagnostic cystoscopy for microscopic hematuria or irritative symptoms. Case group (group-2) comprised of patients with BPE, undergoing TURP. Case group (group-2) was further classified into: Category 2A (patients not on catheter) and category 2B (patients on catheter). All relevant clinical parameters like IPSS, prostate size, Qmax, PVR were recorded. Cystoscopy and bladder biopsy were performed in all patients. Various ultrastructural parameters like myocytes, fascicular pattern, interstitial tissue, nerve hypertrophy and cell junction pattern were analyzed under electron microscope and they were clinically correlated using appropriate statistical tests. Results: Control group had significant difference as compared to case group in terms of baseline parameters like IPSS, flow rate and prostate size, both preoperatively and postoperatively, except for PVR, which was seen only preoperatively. There was statistically significant difference in ultrastructural patterns between case and control group in all five electron microscopic patterns. However, no significant difference was found between the subcategories of case groups. Conclusions: BPE is responsible for ultra structural changes in detrusor muscle and these changes remain persistent even after TURP. Nerve hypertrophy, which was not thoroughly discussed in previous studies, is also one of the salient feature of this study. |
| first_indexed | 2024-12-12T01:55:23Z |
| format | Article |
| id | doaj.art-f2a575728fcd414ba837bca850dc03fe |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-12-12T01:55:23Z |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-f2a575728fcd414ba837bca850dc03fe2022-12-22T00:42:24ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61194361092110110.1590/s1677-5538.ibju.2016.0350S1677-55382017000601092Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlationSher Singh YadavRohit BhattarLokesh SharmaGautam BangaTrilok Chandra SadasukhiABSTRACT Aims: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance. Material and Methods: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group (group-1) consisted of age matched normal male patients, who underwent surveillance or diagnostic cystoscopy for microscopic hematuria or irritative symptoms. Case group (group-2) comprised of patients with BPE, undergoing TURP. Case group (group-2) was further classified into: Category 2A (patients not on catheter) and category 2B (patients on catheter). All relevant clinical parameters like IPSS, prostate size, Qmax, PVR were recorded. Cystoscopy and bladder biopsy were performed in all patients. Various ultrastructural parameters like myocytes, fascicular pattern, interstitial tissue, nerve hypertrophy and cell junction pattern were analyzed under electron microscope and they were clinically correlated using appropriate statistical tests. Results: Control group had significant difference as compared to case group in terms of baseline parameters like IPSS, flow rate and prostate size, both preoperatively and postoperatively, except for PVR, which was seen only preoperatively. There was statistically significant difference in ultrastructural patterns between case and control group in all five electron microscopic patterns. However, no significant difference was found between the subcategories of case groups. Conclusions: BPE is responsible for ultra structural changes in detrusor muscle and these changes remain persistent even after TURP. Nerve hypertrophy, which was not thoroughly discussed in previous studies, is also one of the salient feature of this study.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000601092&lng=en&tlng=enProstatic HyperplasiaProstateUrinary Bladder |
| spellingShingle | Sher Singh Yadav Rohit Bhattar Lokesh Sharma Gautam Banga Trilok Chandra Sadasukhi Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation International Brazilian Journal of Urology Prostatic Hyperplasia Prostate Urinary Bladder |
| title | Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation |
| title_full | Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation |
| title_fullStr | Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation |
| title_full_unstemmed | Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation |
| title_short | Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation |
| title_sort | electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation |
| topic | Prostatic Hyperplasia Prostate Urinary Bladder |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382017000601092&lng=en&tlng=en |
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