Principles of Zebrafish Nephron Segment Development
Nephrons are the functional units which comprise the kidney. Each nephron contains a number of physiologically unique populations of specialized epithelial cells that are organized into discrete domains known as segments. The principles of nephron segment development have been the subject of many st...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Developmental Biology |
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| Online Access: | https://www.mdpi.com/2221-3759/11/1/14 |
| _version_ | 1797610989073465344 |
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| author | Thanh Khoa Nguyen Madeline Petrikas Brooke E. Chambers Rebecca A. Wingert |
| author_facet | Thanh Khoa Nguyen Madeline Petrikas Brooke E. Chambers Rebecca A. Wingert |
| author_sort | Thanh Khoa Nguyen |
| collection | DOAJ |
| description | Nephrons are the functional units which comprise the kidney. Each nephron contains a number of physiologically unique populations of specialized epithelial cells that are organized into discrete domains known as segments. The principles of nephron segment development have been the subject of many studies in recent years. Understanding the mechanisms of nephrogenesis has enormous potential to expand our knowledge about the basis of congenital anomalies of the kidney and urinary tract (CAKUT), and to contribute to ongoing regenerative medicine efforts aimed at identifying renal repair mechanisms and generating replacement kidney tissue. The study of the zebrafish embryonic kidney, or pronephros, provides many opportunities to identify the genes and signaling pathways that control nephron segment development. Here, we describe recent advances of nephron segment patterning and differentiation in the zebrafish, with a focus on distal segment formation. |
| first_indexed | 2024-03-11T06:21:40Z |
| format | Article |
| id | doaj.art-f2a5a70c995d414bbda945c9d9596f81 |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-03-11T06:21:40Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-f2a5a70c995d414bbda945c9d9596f812023-11-17T11:53:50ZengMDPI AGJournal of Developmental Biology2221-37592023-03-011111410.3390/jdb11010014Principles of Zebrafish Nephron Segment DevelopmentThanh Khoa Nguyen0Madeline Petrikas1Brooke E. Chambers2Rebecca A. Wingert3Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USADepartment of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USADepartment of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USADepartment of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USANephrons are the functional units which comprise the kidney. Each nephron contains a number of physiologically unique populations of specialized epithelial cells that are organized into discrete domains known as segments. The principles of nephron segment development have been the subject of many studies in recent years. Understanding the mechanisms of nephrogenesis has enormous potential to expand our knowledge about the basis of congenital anomalies of the kidney and urinary tract (CAKUT), and to contribute to ongoing regenerative medicine efforts aimed at identifying renal repair mechanisms and generating replacement kidney tissue. The study of the zebrafish embryonic kidney, or pronephros, provides many opportunities to identify the genes and signaling pathways that control nephron segment development. Here, we describe recent advances of nephron segment patterning and differentiation in the zebrafish, with a focus on distal segment formation.https://www.mdpi.com/2221-3759/11/1/14nephronsegmentdevelopmentzebrafishdistal tubuleTfap2a |
| spellingShingle | Thanh Khoa Nguyen Madeline Petrikas Brooke E. Chambers Rebecca A. Wingert Principles of Zebrafish Nephron Segment Development Journal of Developmental Biology nephron segment development zebrafish distal tubule Tfap2a |
| title | Principles of Zebrafish Nephron Segment Development |
| title_full | Principles of Zebrafish Nephron Segment Development |
| title_fullStr | Principles of Zebrafish Nephron Segment Development |
| title_full_unstemmed | Principles of Zebrafish Nephron Segment Development |
| title_short | Principles of Zebrafish Nephron Segment Development |
| title_sort | principles of zebrafish nephron segment development |
| topic | nephron segment development zebrafish distal tubule Tfap2a |
| url | https://www.mdpi.com/2221-3759/11/1/14 |
| work_keys_str_mv | AT thanhkhoanguyen principlesofzebrafishnephronsegmentdevelopment AT madelinepetrikas principlesofzebrafishnephronsegmentdevelopment AT brookeechambers principlesofzebrafishnephronsegmentdevelopment AT rebeccaawingert principlesofzebrafishnephronsegmentdevelopment |