Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review
E-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an inherited predisposition of lobular breast carcinoma. In 2019, the international gastric cancer linkage consortium...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/6/1598 |
| _version_ | 1797565133084426240 |
|---|---|
| author | Giovanni Corso Giacomo Montagna Joana Figueiredo Carlo La Vecchia Uberto Fumagalli Romario Maria Sofia Fernandes Susana Seixas Franco Roviello Cristina Trovato Elena Guerini-Rocco Nicola Fusco Gabriella Pravettoni Serena Petrocchi Anna Rotili Giulia Massari Francesca Magnoni Francesca De Lorenzi Manuela Bottoni Viviana Galimberti João Miguel Sanches Mariarosaria Calvello Raquel Seruca Bernardo Bonanni |
| author_facet | Giovanni Corso Giacomo Montagna Joana Figueiredo Carlo La Vecchia Uberto Fumagalli Romario Maria Sofia Fernandes Susana Seixas Franco Roviello Cristina Trovato Elena Guerini-Rocco Nicola Fusco Gabriella Pravettoni Serena Petrocchi Anna Rotili Giulia Massari Francesca Magnoni Francesca De Lorenzi Manuela Bottoni Viviana Galimberti João Miguel Sanches Mariarosaria Calvello Raquel Seruca Bernardo Bonanni |
| author_sort | Giovanni Corso |
| collection | DOAJ |
| description | E-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an inherited predisposition of lobular breast carcinoma. In 2019, the international gastric cancer linkage consortium revised the clinical criteria and established guidelines for the genetic screening of CDH1 germline syndromes. Nevertheless, the introduction of multigene panel testing in clinical practice has led to an increased identification of E-cadherin mutations in individuals without a positive family history of gastric or breast cancers. This observation motivated us to review and present a novel multidisciplinary clinical approach (nutritional, surgical, and image screening) for single subjects who present germline CDH1 mutations but do not fulfil the classic clinical criteria, namely those identified as—(1) incidental finding and (2) individuals with lobular breast cancer without family history of gastric cancer (GC). |
| first_indexed | 2024-03-10T19:07:34Z |
| format | Article |
| id | doaj.art-f2a6213528994edb95c6de014b781656 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:07:34Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f2a6213528994edb95c6de014b7816562023-11-20T04:05:40ZengMDPI AGCancers2072-66942020-06-01126159810.3390/cancers12061598Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical ReviewGiovanni Corso0Giacomo Montagna1Joana Figueiredo2Carlo La Vecchia3Uberto Fumagalli Romario4Maria Sofia Fernandes5Susana Seixas6Franco Roviello7Cristina Trovato8Elena Guerini-Rocco9Nicola Fusco10Gabriella Pravettoni11Serena Petrocchi12Anna Rotili13Giulia Massari14Francesca Magnoni15Francesca De Lorenzi16Manuela Bottoni17Viviana Galimberti18João Miguel Sanches19Mariarosaria Calvello20Raquel Seruca21Bernardo Bonanni22Division of Breast Surgery, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyBreast Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USAi3S—Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, PortugalDepartment of Clinical Sciences and Community Health, University of Milan, 20133 Milan, ItalyDepartment of Digestive Surgery, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, Italyi3S—Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugali3S—Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, PortugalDepartments of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, ItalyDivision of Endoscopy, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, ItalyDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, ItalyDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, ItalyApplied Research Division for Cognitive and Psychological Science, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Breast Imaging, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Breast Surgery, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Breast Surgery, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Plastic Surgery, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Plastic Surgery, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDivision of Breast Surgery, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyInstitute for Systems and Robotics, Instituto Superior Técnico, 1049-001 Lisboa, PortugalDivision of Cancer Prevention and Genetics, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, Italyi3S—Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, PortugalDivision of Cancer Prevention and Genetics, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyE-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an inherited predisposition of lobular breast carcinoma. In 2019, the international gastric cancer linkage consortium revised the clinical criteria and established guidelines for the genetic screening of CDH1 germline syndromes. Nevertheless, the introduction of multigene panel testing in clinical practice has led to an increased identification of E-cadherin mutations in individuals without a positive family history of gastric or breast cancers. This observation motivated us to review and present a novel multidisciplinary clinical approach (nutritional, surgical, and image screening) for single subjects who present germline CDH1 mutations but do not fulfil the classic clinical criteria, namely those identified as—(1) incidental finding and (2) individuals with lobular breast cancer without family history of gastric cancer (GC).https://www.mdpi.com/2072-6694/12/6/1598gastric cancerbreast cancerE-cadherinCDH1 genegermline mutationshereditary syndrome |
| spellingShingle | Giovanni Corso Giacomo Montagna Joana Figueiredo Carlo La Vecchia Uberto Fumagalli Romario Maria Sofia Fernandes Susana Seixas Franco Roviello Cristina Trovato Elena Guerini-Rocco Nicola Fusco Gabriella Pravettoni Serena Petrocchi Anna Rotili Giulia Massari Francesca Magnoni Francesca De Lorenzi Manuela Bottoni Viviana Galimberti João Miguel Sanches Mariarosaria Calvello Raquel Seruca Bernardo Bonanni Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review Cancers gastric cancer breast cancer E-cadherin CDH1 gene germline mutations hereditary syndrome |
| title | Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review |
| title_full | Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review |
| title_fullStr | Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review |
| title_full_unstemmed | Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review |
| title_short | Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review |
| title_sort | hereditary gastric and breast cancer syndromes related to cdh1 germline mutation a multidisciplinary clinical review |
| topic | gastric cancer breast cancer E-cadherin CDH1 gene germline mutations hereditary syndrome |
| url | https://www.mdpi.com/2072-6694/12/6/1598 |
| work_keys_str_mv | AT giovannicorso hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT giacomomontagna hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT joanafigueiredo hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT carlolavecchia hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT ubertofumagalliromario hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT mariasofiafernandes hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT susanaseixas hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT francoroviello hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT cristinatrovato hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT elenaguerinirocco hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT nicolafusco hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT gabriellapravettoni hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT serenapetrocchi hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT annarotili hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT giuliamassari hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT francescamagnoni hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT francescadelorenzi hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT manuelabottoni hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT vivianagalimberti hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT joaomiguelsanches hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT mariarosariacalvello hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT raquelseruca hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview AT bernardobonanni hereditarygastricandbreastcancersyndromesrelatedtocdh1germlinemutationamultidisciplinaryclinicalreview |