Verification of the performance of the Bispectral Index as a hypnotic depth indicator during dexmedetomidine sedation
Background Differences in the effects of propofol and dexmedetomidine sedation on electroencephalogram patterns have been reported previously. However, the reliability of the Bispectral Index (BIS) value for assessing the sedation caused by dexmedetomidine remains debatable. The purpose of this stud...
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| Format: | Article |
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Korean Society of Anesthesiologists
2022-01-01
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| Series: | Anesthesia and Pain Medicine |
| Subjects: | |
| Online Access: | http://www.anesth-pain-med.org/upload/pdf/apm-21065.pdf |
| _version_ | 1797825428369440768 |
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| author | Seunghee Ki Dongeon Lee Wonjin Lee Kwangrae Cho Yongjae Han Jeonghan Lee |
| author_facet | Seunghee Ki Dongeon Lee Wonjin Lee Kwangrae Cho Yongjae Han Jeonghan Lee |
| author_sort | Seunghee Ki |
| collection | DOAJ |
| description | Background Differences in the effects of propofol and dexmedetomidine sedation on electroencephalogram patterns have been reported previously. However, the reliability of the Bispectral Index (BIS) value for assessing the sedation caused by dexmedetomidine remains debatable. The purpose of this study is to evaluate the correlation between the BIS value and the Modified Observer’s Assessment of Alertness/Sedation (MOAA/S) scale in patients sedated with dexmedetomidine. Methods Forty-two patients aged 20–80 years, who were scheduled for surgery under spinal anesthesia were enrolled. Spinal anesthesia was performed using 0.5% bupivacaine, which was followed by dexmedetomidine infusion (loading dose, 0.5–1 μg/kg for 10 min; maintenance dose, 0.3–0.6 μg/kg/h). The MOAA/S score was used to evaluate the level of sedation. Results A total of 215082 MOAA/S scores and BIS data pairs were analyzed. The baseline variability of the BIS value was 7.024%, and BIS value decreased, as the MOAA/S scored decreased. The correlation coefficient and prediction probability between the two measurements were 0.566 (P < 0.0001) and 0.636, respectively. The mean ± standard deviation values of the BIS were 87.22 ± 7.06, 75.85 ± 9.81, and 68.29 ± 12.65 when the MOAA/S scores were 5, 3, and 1, respectively. Furthermore, the cut-off BIS values in the receiver operating characteristic analysis at MOAA/S scores of 5, 3, and 1 were 82, 79, and 73, respectively. Conclusions The BIS values were significantly correlated with the MOAA/S scores. Thus, the BIS along with the clinical sedation scale might prove useful in assessing the hypnotic depth of a patient during sedation with dexmedetomidine. |
| first_indexed | 2024-03-13T10:53:52Z |
| format | Article |
| id | doaj.art-f2a83693732b495186027af76923e06f |
| institution | Directory Open Access Journal |
| issn | 1975-5171 2383-7977 |
| language | English |
| last_indexed | 2024-03-13T10:53:52Z |
| publishDate | 2022-01-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Anesthesia and Pain Medicine |
| spelling | doaj.art-f2a83693732b495186027af76923e06f2023-05-17T05:54:19ZengKorean Society of AnesthesiologistsAnesthesia and Pain Medicine1975-51712383-79772022-01-01171445110.17085/apm.210651101Verification of the performance of the Bispectral Index as a hypnotic depth indicator during dexmedetomidine sedationSeunghee Ki0Dongeon Lee1Wonjin Lee2Kwangrae Cho3Yongjae Han4Jeonghan Lee5 Department of Anesthesiology and Pain Medicine, Inje University College of Medicine, Busan, Korea Department of Anesthesiology and Pain Medicine, Inje University College of Medicine, Busan, Korea Department of Anesthesiology and Pain Medicine, Inje University College of Medicine, Busan, Korea Department of Anesthesiology and Pain Medicine, Inje University College of Medicine, Busan, Korea Department of Anesthesiology and Pain Medicine, Inje University College of Medicine, Busan, Korea Department of Anesthesiology and Pain Medicine, Inje University College of Medicine, Busan, KoreaBackground Differences in the effects of propofol and dexmedetomidine sedation on electroencephalogram patterns have been reported previously. However, the reliability of the Bispectral Index (BIS) value for assessing the sedation caused by dexmedetomidine remains debatable. The purpose of this study is to evaluate the correlation between the BIS value and the Modified Observer’s Assessment of Alertness/Sedation (MOAA/S) scale in patients sedated with dexmedetomidine. Methods Forty-two patients aged 20–80 years, who were scheduled for surgery under spinal anesthesia were enrolled. Spinal anesthesia was performed using 0.5% bupivacaine, which was followed by dexmedetomidine infusion (loading dose, 0.5–1 μg/kg for 10 min; maintenance dose, 0.3–0.6 μg/kg/h). The MOAA/S score was used to evaluate the level of sedation. Results A total of 215082 MOAA/S scores and BIS data pairs were analyzed. The baseline variability of the BIS value was 7.024%, and BIS value decreased, as the MOAA/S scored decreased. The correlation coefficient and prediction probability between the two measurements were 0.566 (P < 0.0001) and 0.636, respectively. The mean ± standard deviation values of the BIS were 87.22 ± 7.06, 75.85 ± 9.81, and 68.29 ± 12.65 when the MOAA/S scores were 5, 3, and 1, respectively. Furthermore, the cut-off BIS values in the receiver operating characteristic analysis at MOAA/S scores of 5, 3, and 1 were 82, 79, and 73, respectively. Conclusions The BIS values were significantly correlated with the MOAA/S scores. Thus, the BIS along with the clinical sedation scale might prove useful in assessing the hypnotic depth of a patient during sedation with dexmedetomidine.http://www.anesth-pain-med.org/upload/pdf/apm-21065.pdfanesthesia, spinalconsciousness monitorsdexmedetomidinehypnotics and sedatives |
| spellingShingle | Seunghee Ki Dongeon Lee Wonjin Lee Kwangrae Cho Yongjae Han Jeonghan Lee Verification of the performance of the Bispectral Index as a hypnotic depth indicator during dexmedetomidine sedation Anesthesia and Pain Medicine anesthesia, spinal consciousness monitors dexmedetomidine hypnotics and sedatives |
| title | Verification of the performance of the Bispectral Index as a hypnotic depth indicator during dexmedetomidine sedation |
| title_full | Verification of the performance of the Bispectral Index as a hypnotic depth indicator during dexmedetomidine sedation |
| title_fullStr | Verification of the performance of the Bispectral Index as a hypnotic depth indicator during dexmedetomidine sedation |
| title_full_unstemmed | Verification of the performance of the Bispectral Index as a hypnotic depth indicator during dexmedetomidine sedation |
| title_short | Verification of the performance of the Bispectral Index as a hypnotic depth indicator during dexmedetomidine sedation |
| title_sort | verification of the performance of the bispectral index as a hypnotic depth indicator during dexmedetomidine sedation |
| topic | anesthesia, spinal consciousness monitors dexmedetomidine hypnotics and sedatives |
| url | http://www.anesth-pain-med.org/upload/pdf/apm-21065.pdf |
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