Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma
Abstract Background This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. Methods The present study reviewed the medical records of patients who received initial treatment a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13048-017-0361-0 |
| _version_ | 1797969792154468352 |
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| author | Yu Zhao Shu Wang Yi-Min Qu Yu-Ting Ji Keng Shen Jing He Lang |
| author_facet | Yu Zhao Shu Wang Yi-Min Qu Yu-Ting Ji Keng Shen Jing He Lang |
| author_sort | Yu Zhao |
| collection | DOAJ |
| description | Abstract Background This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. Methods The present study reviewed the medical records of patients who received initial treatment and a postoperative pathological diagnosis of ovarian endometrioid carcinoma at our center. In all, 78 patients had stage I ovarian endometrioid carcinoma. Results In this series, the 5-year overall survival rate and 5-year disease-free survival (DFS) rates of patients with stage I ovarian endometrioid carcinoma was 98.7% and 87.2%, respectively. Univariate analysis showed the factors that influence the DFS rates include menopausal status, FIGO stage, histological grade, lymphadenectomy, cytology of ascites. Multivariate analysis showed that grade 3 and lymphadenectomy were the independent prognostic factors of DFS for Stage I ovarian endometrioid carcinoma (P = 0.0259, 0.0276 respectively). However, the coexisting endometriosis, concomitant endometrial disorders, dissection of para-aortic lymph node and more courses of thermotherapy had no influence on DFS. Besides, it was found that 19.3% of patients in this series had synchronous early stage and well-to-moderate differentiated endometrial carcinoma. Conclusions Grade 3 and lymphadenectomy were indicated as the independent factors of DFS for stage I patients with ovarian endometrioid carcinoma. The endometrial changes should be considered seriously when fertility-sparing surgery was planned. |
| first_indexed | 2024-04-11T03:07:48Z |
| format | Article |
| id | doaj.art-f2a8db74ef9f450e8867290fd5bef814 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:07:48Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-f2a8db74ef9f450e8867290fd5bef8142023-01-02T12:47:24ZengBMCJournal of Ovarian Research1757-22152017-09-011011910.1186/s13048-017-0361-0Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinomaYu Zhao0Shu Wang1Yi-Min Qu2Yu-Ting Ji3Keng Shen4Jing He Lang5Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical SciencesDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical SciencesSchool of Public Health, Peking Union Medical College & Chinese Academy of Medical SciencesDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical SciencesDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical SciencesDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical SciencesAbstract Background This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. Methods The present study reviewed the medical records of patients who received initial treatment and a postoperative pathological diagnosis of ovarian endometrioid carcinoma at our center. In all, 78 patients had stage I ovarian endometrioid carcinoma. Results In this series, the 5-year overall survival rate and 5-year disease-free survival (DFS) rates of patients with stage I ovarian endometrioid carcinoma was 98.7% and 87.2%, respectively. Univariate analysis showed the factors that influence the DFS rates include menopausal status, FIGO stage, histological grade, lymphadenectomy, cytology of ascites. Multivariate analysis showed that grade 3 and lymphadenectomy were the independent prognostic factors of DFS for Stage I ovarian endometrioid carcinoma (P = 0.0259, 0.0276 respectively). However, the coexisting endometriosis, concomitant endometrial disorders, dissection of para-aortic lymph node and more courses of thermotherapy had no influence on DFS. Besides, it was found that 19.3% of patients in this series had synchronous early stage and well-to-moderate differentiated endometrial carcinoma. Conclusions Grade 3 and lymphadenectomy were indicated as the independent factors of DFS for stage I patients with ovarian endometrioid carcinoma. The endometrial changes should be considered seriously when fertility-sparing surgery was planned.http://link.springer.com/article/10.1186/s13048-017-0361-0Ovarian endometrioid carcinomaStage I diseasePrognosis |
| spellingShingle | Yu Zhao Shu Wang Yi-Min Qu Yu-Ting Ji Keng Shen Jing He Lang Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma Journal of Ovarian Research Ovarian endometrioid carcinoma Stage I disease Prognosis |
| title | Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma |
| title_full | Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma |
| title_fullStr | Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma |
| title_full_unstemmed | Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma |
| title_short | Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma |
| title_sort | prognostic analysis for chinese patients with stage i ovarian endometrioid carcinoma |
| topic | Ovarian endometrioid carcinoma Stage I disease Prognosis |
| url | http://link.springer.com/article/10.1186/s13048-017-0361-0 |
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